A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones

Mohammed H. Geesi; Azzam Ahmed Mohammed Al-Hadedi; Mohammed A. Bakht; Abdellah Kaiba; Meryem Boukili; Mohammed B. Alshammari; Oussama Dehbi; Yassine Riadi

doi:10.1080/17518253.2018.1536228

A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones

Mohammed H. Geesi, Azzam Ahmed Mohammed Al-Hadedi, Mohammed A. Bakht, Abdellah Kaiba, Meryem Boukili, Mohammed B. Alshammari, Oussama Dehbi, Yassine Riadi

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

An eco-friendly and efficient method was developed for the preparation of a new series of sulfur-containing quinolinthiones. Compounds 6a–o were synthesized from 4-methyl-2-thiocoumarin and arylhydrazides using water as a solvent under microwave irradiation. Some noteworthy features of our novel method are its cleanliness, short reaction time and high conversion rate, and the reaction proceeds (profiles) using a simple procedure. All of the prepared compounds were screened for their antibacterial efficacy in vitro using the disc diffusion method against bacterial strains. Compound (6j) showed the greatest potency with a 16 and 19 mm inhibition zone against Klebsiella pneumonia and Staphylococcus aureus, respectively.

Original language	English
Pages (from-to)	469-475
Number of pages	7
Journal	Green Chemistry Letters and Reviews
Volume	11
Issue number	4
DOIs	https://doi.org/10.1080/17518253.2018.1536228
State	Published - 2 Oct 2018

Keywords

Green chemistry
Methyl-2-thiocoumarin
Microwave
Quinolinthiones
Water

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/17518253.2018.1536228

Cite this

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title = "A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones",

abstract = "An eco-friendly and efficient method was developed for the preparation of a new series of sulfur-containing quinolinthiones. Compounds 6a–o were synthesized from 4-methyl-2-thiocoumarin and arylhydrazides using water as a solvent under microwave irradiation. Some noteworthy features of our novel method are its cleanliness, short reaction time and high conversion rate, and the reaction proceeds (profiles) using a simple procedure. All of the prepared compounds were screened for their antibacterial efficacy in vitro using the disc diffusion method against bacterial strains. Compound (6j) showed the greatest potency with a 16 and 19 mm inhibition zone against Klebsiella pneumonia and Staphylococcus aureus, respectively.",

keywords = "Green chemistry, Methyl-2-thiocoumarin, Microwave, Quinolinthiones, Water",

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doi = "10.1080/17518253.2018.1536228",

language = "English",

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T1 - A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones

AU - Geesi, Mohammed H.

AU - Al-Hadedi, Azzam Ahmed Mohammed

AU - Bakht, Mohammed A.

AU - Kaiba, Abdellah

AU - Boukili, Meryem

AU - Alshammari, Mohammed B.

AU - Dehbi, Oussama

AU - Riadi, Yassine

PY - 2018/10/2

Y1 - 2018/10/2

N2 - An eco-friendly and efficient method was developed for the preparation of a new series of sulfur-containing quinolinthiones. Compounds 6a–o were synthesized from 4-methyl-2-thiocoumarin and arylhydrazides using water as a solvent under microwave irradiation. Some noteworthy features of our novel method are its cleanliness, short reaction time and high conversion rate, and the reaction proceeds (profiles) using a simple procedure. All of the prepared compounds were screened for their antibacterial efficacy in vitro using the disc diffusion method against bacterial strains. Compound (6j) showed the greatest potency with a 16 and 19 mm inhibition zone against Klebsiella pneumonia and Staphylococcus aureus, respectively.

AB - An eco-friendly and efficient method was developed for the preparation of a new series of sulfur-containing quinolinthiones. Compounds 6a–o were synthesized from 4-methyl-2-thiocoumarin and arylhydrazides using water as a solvent under microwave irradiation. Some noteworthy features of our novel method are its cleanliness, short reaction time and high conversion rate, and the reaction proceeds (profiles) using a simple procedure. All of the prepared compounds were screened for their antibacterial efficacy in vitro using the disc diffusion method against bacterial strains. Compound (6j) showed the greatest potency with a 16 and 19 mm inhibition zone against Klebsiella pneumonia and Staphylococcus aureus, respectively.

KW - Green chemistry

KW - Methyl-2-thiocoumarin

KW - Microwave

KW - Quinolinthiones

KW - Water

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JO - Green Chemistry Letters and Reviews

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IS - 4

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A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones

Abstract

Keywords

UN SDGs

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