A review on anticancer potential of bioactive heterocycle quinoline

Obaid Afzal; Suresh Kumar; Md Rafi Haider; Md Rahmat Ali; Rajiv Kumar; Manu Jaggi; Sandhya Bawa

doi:10.1016/j.ejmech.2014.07.044

A review on anticancer potential of bioactive heterocycle quinoline

Obaid Afzal, Suresh Kumar, Md Rafi Haider, Md Rahmat Ali, Rajiv Kumar, Manu Jaggi, Sandhya Bawa

Research output: Contribution to journal › Review article › peer-review

726 Scopus citations

Abstract

The advent of Camptothecin added a new dimension in the field anticancer drug development containing quinoline motif. Quinoline scaffold plays an important role in anticancer drug development as their derivatives have shown excellent results through different mechanism of action such as growth inhibitors by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness. The anti-cancer potential of several of these derivatives have been demonstrated on various cancer cell lines. In this review we have compiled and discussed specifically the anticancer potential of quinoline derivatives, which could provide a low-height flying bird's eye view of the quinoline derived compounds to a medicinal chemist for a comprehensive and target oriented information for development of clinically viable anticancer drugs.

Original language	English
Pages (from-to)	871-910
Number of pages	40
Journal	European Journal of Medicinal Chemistry
Volume	97
Issue number	1
DOIs	https://doi.org/10.1016/j.ejmech.2014.07.044
State	Published - 2015
Externally published	Yes

Keywords

Anticancer
Drug development
Quinoline

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2014.07.044

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title = "A review on anticancer potential of bioactive heterocycle quinoline",

abstract = "The advent of Camptothecin added a new dimension in the field anticancer drug development containing quinoline motif. Quinoline scaffold plays an important role in anticancer drug development as their derivatives have shown excellent results through different mechanism of action such as growth inhibitors by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness. The anti-cancer potential of several of these derivatives have been demonstrated on various cancer cell lines. In this review we have compiled and discussed specifically the anticancer potential of quinoline derivatives, which could provide a low-height flying bird's eye view of the quinoline derived compounds to a medicinal chemist for a comprehensive and target oriented information for development of clinically viable anticancer drugs.",

keywords = "Anticancer, Drug development, Quinoline",

author = "Obaid Afzal and Suresh Kumar and Haider, \{Md Rafi\} and Ali, \{Md Rahmat\} and Rajiv Kumar and Manu Jaggi and Sandhya Bawa",

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year = "2015",

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language = "English",

volume = "97",

pages = "871--910",

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T1 - A review on anticancer potential of bioactive heterocycle quinoline

AU - Afzal, Obaid

AU - Kumar, Suresh

AU - Haider, Md Rafi

AU - Ali, Md Rahmat

AU - Kumar, Rajiv

AU - Jaggi, Manu

AU - Bawa, Sandhya

PY - 2015

Y1 - 2015

N2 - The advent of Camptothecin added a new dimension in the field anticancer drug development containing quinoline motif. Quinoline scaffold plays an important role in anticancer drug development as their derivatives have shown excellent results through different mechanism of action such as growth inhibitors by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness. The anti-cancer potential of several of these derivatives have been demonstrated on various cancer cell lines. In this review we have compiled and discussed specifically the anticancer potential of quinoline derivatives, which could provide a low-height flying bird's eye view of the quinoline derived compounds to a medicinal chemist for a comprehensive and target oriented information for development of clinically viable anticancer drugs.

AB - The advent of Camptothecin added a new dimension in the field anticancer drug development containing quinoline motif. Quinoline scaffold plays an important role in anticancer drug development as their derivatives have shown excellent results through different mechanism of action such as growth inhibitors by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness. The anti-cancer potential of several of these derivatives have been demonstrated on various cancer cell lines. In this review we have compiled and discussed specifically the anticancer potential of quinoline derivatives, which could provide a low-height flying bird's eye view of the quinoline derived compounds to a medicinal chemist for a comprehensive and target oriented information for development of clinically viable anticancer drugs.

KW - Anticancer

KW - Drug development

KW - Quinoline

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DO - 10.1016/j.ejmech.2014.07.044

M3 - Review article

C2 - 25073919

AN - SCOPUS:84937217164

SN - 0223-5234

VL - 97

SP - 871

EP - 910

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 1

ER -

A review on anticancer potential of bioactive heterocycle quinoline

Abstract

Keywords

UN SDGs

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