TY - JOUR
T1 - 2-Methoxy-6-Acetyl-7-Methyljuglone
T2 - A Bioactive Phytochemical with Potential Pharmacological Activities
AU - Khalil, Atif Ali Khan
AU - Qazi, Asma Saleem
AU - Nasir, Abdul
AU - Ahn, Mi Jeong
AU - Shah, Muhammad Ajmal
AU - Ahmad, Muhammad Saad
AU - Sajjad, Wasim
AU - Ali, Tahir
AU - Naeem, Muhammad
AU - Shah, Fawad Ali
AU - Khan, Muhammad Tufail Ahmed
AU - Romman, Muhammad
AU - Rehman, Shahfiq Ur
AU - Haider, Adnan
AU - Noor, Raishma
N1 - Publisher Copyright:
© 2022 Bentham Science Publishers.
PY - 2022/2
Y1 - 2022/2
N2 - Natural products have been the focus of biomedical and pharmaceutical research to develop new therapies in recent years. 2-methoxy-6-acetyl-7-methyljuglone (2-methoxystypandrone, MAM) a natural bioactive juglone deriva-tive, is known to have various levels of pharmacotherapeutic efficacies as an anti-inflammatory, anticancer, antioxi-dant, antimicrobial, and anti-HIV activities. MAM fights cancer progression by inducing apoptosis, necroptosis and deregulating signaling pathways through H2O2-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activa-tion, and the RIP1/RIP3 complex. In this review, we summarize the pharmacological importance of MAM in the field of drug discovery. Furthermore, this review not only emphasizes the medicinal properties of MAM, but also discusses its potential efficacy in future medicinal products.
AB - Natural products have been the focus of biomedical and pharmaceutical research to develop new therapies in recent years. 2-methoxy-6-acetyl-7-methyljuglone (2-methoxystypandrone, MAM) a natural bioactive juglone deriva-tive, is known to have various levels of pharmacotherapeutic efficacies as an anti-inflammatory, anticancer, antioxi-dant, antimicrobial, and anti-HIV activities. MAM fights cancer progression by inducing apoptosis, necroptosis and deregulating signaling pathways through H2O2-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activa-tion, and the RIP1/RIP3 complex. In this review, we summarize the pharmacological importance of MAM in the field of drug discovery. Furthermore, this review not only emphasizes the medicinal properties of MAM, but also discusses its potential efficacy in future medicinal products.
KW - 2-Methoxy-6-acetyl-7-methyljuglone
KW - Anti-inflammatory
KW - Antibacterial
KW - Anticancer
KW - Antioxidant
KW - MAPK
UR - http://www.scopus.com/inward/record.url?scp=85125053868&partnerID=8YFLogxK
U2 - 10.2174/1871520621666210623095636
DO - 10.2174/1871520621666210623095636
M3 - Review article
C2 - 34165415
AN - SCOPUS:85125053868
SN - 1871-5206
VL - 22
SP - 687
EP - 693
JO - Anti-Cancer Agents in Medicinal Chemistry
JF - Anti-Cancer Agents in Medicinal Chemistry
IS - 4
ER -
