2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities

Atif Ali Khan Khalil; Asma Saleem Qazi; Abdul Nasir; Mi Jeong Ahn; Muhammad Ajmal Shah; Muhammad Saad Ahmad; Wasim Sajjad; Tahir Ali; Muhammad Naeem; Fawad Ali Shah; Muhammad Tufail Ahmed Khan; Muhammad Romman; Shahfiq Ur Rehman; Adnan Haider; Raishma Noor

doi:10.2174/1871520621666210623095636

2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities

Atif Ali Khan Khalil
, Asma Saleem Qazi
, Abdul Nasir
, Mi Jeong Ahn
, Muhammad Ajmal Shah
, Muhammad Saad Ahmad
, Wasim Sajjad
, Tahir Ali
, Muhammad Naeem
, Fawad Ali Shah
, Muhammad Tufail Ahmed Khan
, Muhammad Romman
, Shahfiq Ur Rehman
, Adnan Haider
, Raishma Noor

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Natural products have been the focus of biomedical and pharmaceutical research to develop new therapies in recent years. 2-methoxy-6-acetyl-7-methyljuglone (2-methoxystypandrone, MAM) a natural bioactive juglone deriva-tive, is known to have various levels of pharmacotherapeutic efficacies as an anti-inflammatory, anticancer, antioxi-dant, antimicrobial, and anti-HIV activities. MAM fights cancer progression by inducing apoptosis, necroptosis and deregulating signaling pathways through H₂O₂-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activa-tion, and the RIP1/RIP3 complex. In this review, we summarize the pharmacological importance of MAM in the field of drug discovery. Furthermore, this review not only emphasizes the medicinal properties of MAM, but also discusses its potential efficacy in future medicinal products.

Original language	English
Pages (from-to)	687-693
Number of pages	7
Journal	Anti-Cancer Agents in Medicinal Chemistry
Volume	22
Issue number	4
DOIs	https://doi.org/10.2174/1871520621666210623095636
State	Published - Feb 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

2-Methoxy-6-acetyl-7-methyljuglone
Anti-inflammatory
Antibacterial
Anticancer
Antioxidant
MAPK

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10.2174/1871520621666210623095636

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Khalil, A. A. K., Qazi, A. S., Nasir, A., Ahn, M. J., Shah, M. A., Ahmad, M. S., Sajjad, W., Ali, T., Naeem, M., Shah, F. A., Khan, M. T. A., Romman, M., Rehman, S. U., Haider, A., & Noor, R. (2022). 2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities. Anti-Cancer Agents in Medicinal Chemistry, 22(4), 687-693. https://doi.org/10.2174/1871520621666210623095636

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title = "2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities",

abstract = "Natural products have been the focus of biomedical and pharmaceutical research to develop new therapies in recent years. 2-methoxy-6-acetyl-7-methyljuglone (2-methoxystypandrone, MAM) a natural bioactive juglone deriva-tive, is known to have various levels of pharmacotherapeutic efficacies as an anti-inflammatory, anticancer, antioxi-dant, antimicrobial, and anti-HIV activities. MAM fights cancer progression by inducing apoptosis, necroptosis and deregulating signaling pathways through H2O2-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activa-tion, and the RIP1/RIP3 complex. In this review, we summarize the pharmacological importance of MAM in the field of drug discovery. Furthermore, this review not only emphasizes the medicinal properties of MAM, but also discusses its potential efficacy in future medicinal products.",

keywords = "2-Methoxy-6-acetyl-7-methyljuglone, Anti-inflammatory, Antibacterial, Anticancer, Antioxidant, MAPK",

author = "Khalil, \{Atif Ali Khan\} and Qazi, \{Asma Saleem\} and Abdul Nasir and Ahn, \{Mi Jeong\} and Shah, \{Muhammad Ajmal\} and Ahmad, \{Muhammad Saad\} and Wasim Sajjad and Tahir Ali and Muhammad Naeem and Shah, \{Fawad Ali\} and Khan, \{Muhammad Tufail Ahmed\} and Muhammad Romman and Rehman, \{Shahfiq Ur\} and Adnan Haider and Raishma Noor",

note = "Publisher Copyright: {\textcopyright} 2022 Bentham Science Publishers.",

year = "2022",

month = feb,

doi = "10.2174/1871520621666210623095636",

language = "English",

volume = "22",

pages = "687--693",

journal = "Anti-Cancer Agents in Medicinal Chemistry",

issn = "1871-5206",

publisher = "Bentham Science Publishers",

number = "4",

}

Khalil, AAK, Qazi, AS, Nasir, A, Ahn, MJ, Shah, MA, Ahmad, MS, Sajjad, W, Ali, T, Naeem, M, Shah, FA, Khan, MTA, Romman, M, Rehman, SU, Haider, A & Noor, R 2022, '2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities', Anti-Cancer Agents in Medicinal Chemistry, vol. 22, no. 4, pp. 687-693. https://doi.org/10.2174/1871520621666210623095636

TY - JOUR

T1 - 2-Methoxy-6-Acetyl-7-Methyljuglone

T2 - A Bioactive Phytochemical with Potential Pharmacological Activities

AU - Khalil, Atif Ali Khan

AU - Qazi, Asma Saleem

AU - Nasir, Abdul

AU - Ahn, Mi Jeong

AU - Shah, Muhammad Ajmal

AU - Ahmad, Muhammad Saad

AU - Sajjad, Wasim

AU - Ali, Tahir

AU - Naeem, Muhammad

AU - Shah, Fawad Ali

AU - Khan, Muhammad Tufail Ahmed

AU - Romman, Muhammad

AU - Rehman, Shahfiq Ur

AU - Haider, Adnan

AU - Noor, Raishma

PY - 2022/2

Y1 - 2022/2

N2 - Natural products have been the focus of biomedical and pharmaceutical research to develop new therapies in recent years. 2-methoxy-6-acetyl-7-methyljuglone (2-methoxystypandrone, MAM) a natural bioactive juglone deriva-tive, is known to have various levels of pharmacotherapeutic efficacies as an anti-inflammatory, anticancer, antioxi-dant, antimicrobial, and anti-HIV activities. MAM fights cancer progression by inducing apoptosis, necroptosis and deregulating signaling pathways through H2O2-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activa-tion, and the RIP1/RIP3 complex. In this review, we summarize the pharmacological importance of MAM in the field of drug discovery. Furthermore, this review not only emphasizes the medicinal properties of MAM, but also discusses its potential efficacy in future medicinal products.

AB - Natural products have been the focus of biomedical and pharmaceutical research to develop new therapies in recent years. 2-methoxy-6-acetyl-7-methyljuglone (2-methoxystypandrone, MAM) a natural bioactive juglone deriva-tive, is known to have various levels of pharmacotherapeutic efficacies as an anti-inflammatory, anticancer, antioxi-dant, antimicrobial, and anti-HIV activities. MAM fights cancer progression by inducing apoptosis, necroptosis and deregulating signaling pathways through H2O2-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activa-tion, and the RIP1/RIP3 complex. In this review, we summarize the pharmacological importance of MAM in the field of drug discovery. Furthermore, this review not only emphasizes the medicinal properties of MAM, but also discusses its potential efficacy in future medicinal products.

KW - 2-Methoxy-6-acetyl-7-methyljuglone

KW - Anti-inflammatory

KW - Antibacterial

KW - Anticancer

KW - Antioxidant

KW - MAPK

UR - https://www.scopus.com/pages/publications/85125053868

U2 - 10.2174/1871520621666210623095636

DO - 10.2174/1871520621666210623095636

M3 - Review article

C2 - 34165415

AN - SCOPUS:85125053868

SN - 1871-5206

VL - 22

SP - 687

EP - 693

JO - Anti-Cancer Agents in Medicinal Chemistry

JF - Anti-Cancer Agents in Medicinal Chemistry

IS - 4

ER -

2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities

Abstract

UN SDGs

Keywords

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