Design, molecular docking, synthesis, and anticancer activity of novel benzothiazolyl piperidine3carboxamide derivatives as CDK inhibitors

Pharmacology, Toxicology and Pharmaceutical Science

1. Phosphotransferase Inhibitor 100%
2. Malignant Neoplasm 68%
3. Receptor 31%
4. Anticarcinogen 31%
5. IC50 26%
6. Neoplasm 21%
7. Cyclin Dependent Kinase 2 15%
8. Drug Resistance 15%
9. Adverse Effect 15%
10. Binding Site 10%
11. Mortality Rate 10%
12. Pharmaceutical Chemistry 10%
13. Hydrogen Bond 10%
14. Protein Kinase 10%
15. Vasculotropin 10%
16. Sorafenib 10%
17. Sulforhodamine B 10%
18. Combination Therapy 5%
19. Chronic Lymphatic Leukemia 5%
20. Clinical Trial 5%
21. Adenosine Triphosphate 5%
22. Prostate Cancer 5%
23. Structure Activity Relationship 5%
24. Diseases 5%
25. Benzothiazole 5%
26. Cancer Chemotherapy 5%
27. Ribose 5%
28. Cyclin Dependent Kinase 9 5%
29. Breast Cancer 5%
30. Cellular Processes 5%
31. Leukemia 5%
32. Phosphotransferase 5%
33. Thiazole 5%
34. Solid Malignant Neoplasm 5%
35. Phorbol 12,13-dibutyrate 5%
36. Carboxamide 5%
37. Lung Cancer 5%
38. Oxazole 5%
39. Hematologic Malignancy 5%
40. Drug Development 5%
41. Cancer Growth 5%
42. Morbidity 5%
43. Enzyme 5%
44. Nitrogen 5%
45. Lipid 5%
46. Fox 5%
47. Carbohydrate 5%
48. Hydrogen 5%