Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation

Oussama Dehbi; Esam A. Ishak; Mohammed A. Bakht; Mohammed H. Geesi; Mohammed B. Alshammari; Vincent Chagnault; Abdellah Kaiba; Saïd Lazar; Yassine Riadi

doi:10.1080/17518253.2018.1437225

Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation

Oussama Dehbi, Esam A. Ishak, Mohammed A. Bakht, Mohammed H. Geesi, Mohammed B. Alshammari, Vincent Chagnault, Abdellah Kaiba, Saïd Lazar, Yassine Riadi

Research output: Contribution to journal › Letter › peer-review

21 Scopus citations

Abstract

An efficient and ecofriendly method for the synthesis of disubstituted 5-aminopyrimidines from vinyl azides and urea or thiourea was developed. This reaction proceeds under microwave irradiation conditions in the presence of water as a solvent. The remarkable features of this new protocol are high conversion, short reaction times, cleaner reaction profiles and straightforward procedure.

Original language	English
Pages (from-to)	62-66
Number of pages	5
Journal	Green Chemistry Letters and Reviews
Volume	11
Issue number	2
DOIs	https://doi.org/10.1080/17518253.2018.1437225
State	Published - 3 Apr 2018

Keywords

disubstituted 5-aminopyrimidines
Green chemistry
microwaves
vinyl azide
water

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10.1080/17518253.2018.1437225

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title = "Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation",

abstract = "An efficient and ecofriendly method for the synthesis of disubstituted 5-aminopyrimidines from vinyl azides and urea or thiourea was developed. This reaction proceeds under microwave irradiation conditions in the presence of water as a solvent. The remarkable features of this new protocol are high conversion, short reaction times, cleaner reaction profiles and straightforward procedure.",

keywords = "disubstituted 5-aminopyrimidines, Green chemistry, microwaves, vinyl azide, water",

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note = "Publisher Copyright: {\textcopyright} 2018 The Author(s). Published by Informa UK Limited, trading as Taylor \& Francis Group.",

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doi = "10.1080/17518253.2018.1437225",

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T1 - Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation

AU - Dehbi, Oussama

AU - Ishak, Esam A.

AU - Bakht, Mohammed A.

AU - Geesi, Mohammed H.

AU - Alshammari, Mohammed B.

AU - Chagnault, Vincent

AU - Kaiba, Abdellah

AU - Lazar, Saïd

AU - Riadi, Yassine

PY - 2018/4/3

Y1 - 2018/4/3

N2 - An efficient and ecofriendly method for the synthesis of disubstituted 5-aminopyrimidines from vinyl azides and urea or thiourea was developed. This reaction proceeds under microwave irradiation conditions in the presence of water as a solvent. The remarkable features of this new protocol are high conversion, short reaction times, cleaner reaction profiles and straightforward procedure.

AB - An efficient and ecofriendly method for the synthesis of disubstituted 5-aminopyrimidines from vinyl azides and urea or thiourea was developed. This reaction proceeds under microwave irradiation conditions in the presence of water as a solvent. The remarkable features of this new protocol are high conversion, short reaction times, cleaner reaction profiles and straightforward procedure.

KW - disubstituted 5-aminopyrimidines

KW - Green chemistry

KW - microwaves

KW - vinyl azide

KW - water

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U2 - 10.1080/17518253.2018.1437225

DO - 10.1080/17518253.2018.1437225

M3 - Letter

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SN - 1751-8253

VL - 11

SP - 62

EP - 66

JO - Green Chemistry Letters and Reviews

JF - Green Chemistry Letters and Reviews

IS - 2

ER -

Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation

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Keywords

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