Utility of 6-amino-2-thiouracils as a core of biologically potent polynitrogen-sulfur fused heterocycles

Samira T. Rabie; Reham A. Abdel-Monem; Nadia R. Mohamed; Ahmed I. Hashem; Afaf A. Nada

doi:10.1002/jhet.1936

Utility of 6-amino-2-thiouracils as a core of biologically potent polynitrogen-sulfur fused heterocycles

Samira T. Rabie
, Reham A. Abdel-Monem
, Nadia R. Mohamed
, Ahmed I. Hashem
, Afaf A. Nada

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

One pot three-component reaction was assisted to form some new pyridopyrimidine derivatives to be investigated as antimicrobial and antitumor agents. The newly synthesized compounds showed high significant antimicrobial activity against the applied strains of both Gram-positive and Gram-negative bacteria and fungi. The cytotoxic activity of some compounds was evaluated as inhibitor of growth in both human liver carcinoma and breast cell lines. The results showed that some compounds exhibited very high cytotoxicity against human liver cell line and breast cancer cells.

Original language	English
Pages (from-to)	E189-E196
Journal	Journal of Heterocyclic Chemistry
Volume	51
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1002/jhet.1936
State	Published - Aug 2014
Externally published	Yes

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10.1002/jhet.1936

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title = "Utility of 6-amino-2-thiouracils as a core of biologically potent polynitrogen-sulfur fused heterocycles",

abstract = "One pot three-component reaction was assisted to form some new pyridopyrimidine derivatives to be investigated as antimicrobial and antitumor agents. The newly synthesized compounds showed high significant antimicrobial activity against the applied strains of both Gram-positive and Gram-negative bacteria and fungi. The cytotoxic activity of some compounds was evaluated as inhibitor of growth in both human liver carcinoma and breast cell lines. The results showed that some compounds exhibited very high cytotoxicity against human liver cell line and breast cancer cells.",

author = "Rabie, \{Samira T.\} and Abdel-Monem, \{Reham A.\} and Mohamed, \{Nadia R.\} and Hashem, \{Ahmed I.\} and Nada, \{Afaf A.\}",

year = "2014",

month = aug,

doi = "10.1002/jhet.1936",

language = "English",

volume = "51",

pages = "E189--E196",

journal = "Journal of Heterocyclic Chemistry",

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T1 - Utility of 6-amino-2-thiouracils as a core of biologically potent polynitrogen-sulfur fused heterocycles

AU - Rabie, Samira T.

AU - Abdel-Monem, Reham A.

AU - Mohamed, Nadia R.

AU - Hashem, Ahmed I.

AU - Nada, Afaf A.

PY - 2014/8

Y1 - 2014/8

N2 - One pot three-component reaction was assisted to form some new pyridopyrimidine derivatives to be investigated as antimicrobial and antitumor agents. The newly synthesized compounds showed high significant antimicrobial activity against the applied strains of both Gram-positive and Gram-negative bacteria and fungi. The cytotoxic activity of some compounds was evaluated as inhibitor of growth in both human liver carcinoma and breast cell lines. The results showed that some compounds exhibited very high cytotoxicity against human liver cell line and breast cancer cells.

AB - One pot three-component reaction was assisted to form some new pyridopyrimidine derivatives to be investigated as antimicrobial and antitumor agents. The newly synthesized compounds showed high significant antimicrobial activity against the applied strains of both Gram-positive and Gram-negative bacteria and fungi. The cytotoxic activity of some compounds was evaluated as inhibitor of growth in both human liver carcinoma and breast cell lines. The results showed that some compounds exhibited very high cytotoxicity against human liver cell line and breast cancer cells.

UR - https://www.scopus.com/pages/publications/84907423712

U2 - 10.1002/jhet.1936

DO - 10.1002/jhet.1936

M3 - Article

AN - SCOPUS:84907423712

SN - 0022-152X

VL - 51

SP - E189-E196

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - SUPPL. 1

ER -

Utility of 6-amino-2-thiouracils as a core of biologically potent polynitrogen-sulfur fused heterocycles

Abstract

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