TY - JOUR
T1 - Unravelling the role of solid lipid nanoparticles in drug delivery
T2 - Journey from laboratory to clinical trial
AU - Harish, Vancha
AU - Mohd, Sharfuddin
AU - Tewari, Devesh
AU - Pandey, Narendra Kumar
AU - Vishwas, Sukriti
AU - Babu, Malakapogu Ravindra
AU - Salkini, Mohamad Ayman
AU - Rehman, Zia ur
AU - Alotaibi, Jehan Talaq
AU - Alotaibi, Renad Fahad
AU - Alrashed, Fahad Abdulaziz
AU - Prasher, Parteek
AU - Sharma, Nitin
AU - Gupta, Gaurav
AU - Jakhmola, Vikash
AU - Singh, Yogendra
AU - Pinto, Terezinha de Jesus Andreoli
AU - Paudel, Keshav Raj
AU - Mittal, Neeraj
AU - Singh, Thakur Gurjeet
AU - Arora, Poonam
AU - Dua, Kamal
AU - Singh, Sachin Kumar
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/8
Y1 - 2023/8
N2 - In current years, solid lipid nanoparticles (SLNs) have gained tremendous interest in research because of their unique characteristics such as encapsulation of drug in their core, targeted drug delivery and their protection from gastrointestinal environment and first pass metabolism of various potential bioactive drugs including proteins, peptides and phytochemicals. The present review discusses the historical background and transformation taken place in the nanotechnology that led to the development of SLNs. Further, the study entailed about the composition, various ingredients and techniques that are used to fabricate SLNs along with their mechanism and advantages. Highlighted are the biopharmaceutical aspects and bottle necks associated to clinical translation of SLNs for improving the bioavailability, stability, and solubility of various lipophilic and gastrointestinal labile drugs that are used for treating many chronic diseases.
AB - In current years, solid lipid nanoparticles (SLNs) have gained tremendous interest in research because of their unique characteristics such as encapsulation of drug in their core, targeted drug delivery and their protection from gastrointestinal environment and first pass metabolism of various potential bioactive drugs including proteins, peptides and phytochemicals. The present review discusses the historical background and transformation taken place in the nanotechnology that led to the development of SLNs. Further, the study entailed about the composition, various ingredients and techniques that are used to fabricate SLNs along with their mechanism and advantages. Highlighted are the biopharmaceutical aspects and bottle necks associated to clinical translation of SLNs for improving the bioavailability, stability, and solubility of various lipophilic and gastrointestinal labile drugs that are used for treating many chronic diseases.
KW - Biopharmaceutical aspects
KW - Oral bioavailability
KW - Solid lipid nanoparticles
KW - Solubility
UR - https://www.scopus.com/pages/publications/85160856743
U2 - 10.1016/j.jddst.2023.104616
DO - 10.1016/j.jddst.2023.104616
M3 - Review article
AN - SCOPUS:85160856743
SN - 1773-2247
VL - 85
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 104616
ER -