Ultrasonographic changes in median nerve cross-sectional area in the elderly: effects of aging and type 2 diabetes

Mohamed A. Bedewi; Ezzat M. Awad; Mamdouh Ali Kotb; Sanaa Moharram Kamal; Saleh M. Alfawaz; NAIF ABDURHMAN ALRUDIAN; Steven B. Soliman; Daifallah Mohamed Almalki; Ali Abdullah AlAseeri; Bader A. Alhariqi; mohammed Saad alqahtani; Abdullah F. Alfawaz; Sherine M. Swify

doi:10.1186/s12877-025-06765-0

Ultrasonographic changes in median nerve cross-sectional area in the elderly: effects of aging and type 2 diabetes

Mohamed A. Bedewi
, Ezzat M. Awad
, Mamdouh Ali Kotb
, Sanaa Moharram Kamal
, Saleh M. Alfawaz
, NAIF ABDURHMAN ALRUDIAN
, Steven B. Soliman
, Daifallah Mohamed Almalki
, Ali Abdullah AlAseeri
, Bader A. Alhariqi
, mohammed Saad alqahtani
, Abdullah F. Alfawaz
, Sherine M. Swify

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The aim of this study is to investigate the effects of aging and type 2 diabetes on the cross-sectional area (CSA) of the median nerve in elderly subjects. Materials and methods: The study sample included 101 elderly participants (34 non-T2D and 67 with T2D ; mean age 65.3 years. A young cohort included 130 additional adult participants (75 non-T2D, and 55 T2D); mean age 45 years. Results: The median nerve CSA in the elderly T2Dc group was larger compared to the young group. Both the young and elderly T2D groups showed larger median nerve cross-sectional area (MNCSA) compared to the elderlyT2D group. The elderly T2D group demonstrated a larger MNCSA compared to the elderly non-T2D group. Conclusion: Our findings reveal that elderly individuals showed larger MNCSA, whether or not they have diabetes, compared to young group. These findings suggest that aging is a dominant factor in the increase in MNCSA and that T2D may exacerbate it We propose that changes in MNCSA associated with diabetes could be part of the normal aging process, rather than representing an independent pathology.

Original language	English
Article number	1044
Journal	BMC Geriatrics
Volume	25
Issue number	1
DOIs	https://doi.org/10.1186/s12877-025-06765-0
State	Published - Dec 2025

Keywords

Aging, median nerve, type 2 diabetes, peripheral nerves
Cross-sectional area
Reference values
Ultrasound

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10.1186/s12877-025-06765-0

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Bedewi, M. A., Awad, E. M., Kotb, M. A., Moharram Kamal, S., Alfawaz, S. M., ABDURHMAN ALRUDIAN, NAIF., Soliman, S. B., Almalki, D. M., AlAseeri, A. A., Alhariqi, B. A., Saad alqahtani, M., Alfawaz, A. F., & Swify, S. M. (2025). Ultrasonographic changes in median nerve cross-sectional area in the elderly: effects of aging and type 2 diabetes. BMC Geriatrics, 25(1), Article 1044. https://doi.org/10.1186/s12877-025-06765-0

@article{6aed7cf0ad15482b9fb0d489aed59a46,

title = "Ultrasonographic changes in median nerve cross-sectional area in the elderly: effects of aging and type 2 diabetes",

abstract = "Objective: The aim of this study is to investigate the effects of aging and type 2 diabetes on the cross-sectional area (CSA) of the median nerve in elderly subjects. Materials and methods: The study sample included 101 elderly participants (34 non-T2D and 67 with T2D ; mean age 65.3 years. A young cohort included 130 additional adult participants (75 non-T2D, and 55 T2D); mean age 45 years. Results: The median nerve CSA in the elderly T2Dc group was larger compared to the young group. Both the young and elderly T2D groups showed larger median nerve cross-sectional area (MNCSA) compared to the elderlyT2D group. The elderly T2D group demonstrated a larger MNCSA compared to the elderly non-T2D group. Conclusion: Our findings reveal that elderly individuals showed larger MNCSA, whether or not they have diabetes, compared to young group. These findings suggest that aging is a dominant factor in the increase in MNCSA and that T2D may exacerbate it We propose that changes in MNCSA associated with diabetes could be part of the normal aging process, rather than representing an independent pathology.",

keywords = "Aging, median nerve, type 2 diabetes, peripheral nerves, Cross-sectional area, Reference values, Ultrasound",

author = "Bedewi, \{Mohamed A.\} and Awad, \{Ezzat M.\} and Kotb, \{Mamdouh Ali\} and \{Moharram Kamal\}, Sanaa and Alfawaz, \{Saleh M.\} and \{ABDURHMAN ALRUDIAN\}, NAIF and Soliman, \{Steven B.\} and Almalki, \{Daifallah Mohamed\} and AlAseeri, \{Ali Abdullah\} and Alhariqi, \{Bader A.\} and \{Saad alqahtani\}, mohammed and Alfawaz, \{Abdullah F.\} and Swify, \{Sherine M.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = dec,

doi = "10.1186/s12877-025-06765-0",

language = "English",

volume = "25",

journal = "BMC Geriatrics",

issn = "1471-2318",

publisher = "BioMed Central Ltd",

number = "1",

}

Bedewi, MA, Awad, EM, Kotb, MA , Moharram Kamal, S, Alfawaz, SM, ABDURHMAN ALRUDIAN, NAIF, Soliman, SB, Almalki, DM , AlAseeri, AA, Alhariqi, BA, Saad alqahtani, M , Alfawaz, AF & Swify, SM 2025, 'Ultrasonographic changes in median nerve cross-sectional area in the elderly: effects of aging and type 2 diabetes', BMC Geriatrics, vol. 25, no. 1, 1044. https://doi.org/10.1186/s12877-025-06765-0

TY - JOUR

T1 - Ultrasonographic changes in median nerve cross-sectional area in the elderly

T2 - effects of aging and type 2 diabetes

AU - Bedewi, Mohamed A.

AU - Awad, Ezzat M.

AU - Kotb, Mamdouh Ali

AU - Moharram Kamal, Sanaa

AU - Alfawaz, Saleh M.

AU - ABDURHMAN ALRUDIAN, NAIF

AU - Soliman, Steven B.

AU - Almalki, Daifallah Mohamed

AU - AlAseeri, Ali Abdullah

AU - Alhariqi, Bader A.

AU - Saad alqahtani, mohammed

AU - Alfawaz, Abdullah F.

AU - Swify, Sherine M.

PY - 2025/12

Y1 - 2025/12

N2 - Objective: The aim of this study is to investigate the effects of aging and type 2 diabetes on the cross-sectional area (CSA) of the median nerve in elderly subjects. Materials and methods: The study sample included 101 elderly participants (34 non-T2D and 67 with T2D ; mean age 65.3 years. A young cohort included 130 additional adult participants (75 non-T2D, and 55 T2D); mean age 45 years. Results: The median nerve CSA in the elderly T2Dc group was larger compared to the young group. Both the young and elderly T2D groups showed larger median nerve cross-sectional area (MNCSA) compared to the elderlyT2D group. The elderly T2D group demonstrated a larger MNCSA compared to the elderly non-T2D group. Conclusion: Our findings reveal that elderly individuals showed larger MNCSA, whether or not they have diabetes, compared to young group. These findings suggest that aging is a dominant factor in the increase in MNCSA and that T2D may exacerbate it We propose that changes in MNCSA associated with diabetes could be part of the normal aging process, rather than representing an independent pathology.

AB - Objective: The aim of this study is to investigate the effects of aging and type 2 diabetes on the cross-sectional area (CSA) of the median nerve in elderly subjects. Materials and methods: The study sample included 101 elderly participants (34 non-T2D and 67 with T2D ; mean age 65.3 years. A young cohort included 130 additional adult participants (75 non-T2D, and 55 T2D); mean age 45 years. Results: The median nerve CSA in the elderly T2Dc group was larger compared to the young group. Both the young and elderly T2D groups showed larger median nerve cross-sectional area (MNCSA) compared to the elderlyT2D group. The elderly T2D group demonstrated a larger MNCSA compared to the elderly non-T2D group. Conclusion: Our findings reveal that elderly individuals showed larger MNCSA, whether or not they have diabetes, compared to young group. These findings suggest that aging is a dominant factor in the increase in MNCSA and that T2D may exacerbate it We propose that changes in MNCSA associated with diabetes could be part of the normal aging process, rather than representing an independent pathology.

KW - Aging, median nerve, type 2 diabetes, peripheral nerves

KW - Cross-sectional area

KW - Reference values

KW - Ultrasound

UR - https://www.scopus.com/pages/publications/105026321871

U2 - 10.1186/s12877-025-06765-0

DO - 10.1186/s12877-025-06765-0

M3 - Article

C2 - 41275078

AN - SCOPUS:105026321871

SN - 1471-2318

VL - 25

JO - BMC Geriatrics

JF - BMC Geriatrics

IS - 1

M1 - 1044

ER -

Ultrasonographic changes in median nerve cross-sectional area in the elderly: effects of aging and type 2 diabetes

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Keywords

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