TY - JOUR
T1 - Toll-like receptor 9 gene polymorphism in chronic and aggressive periodontitis patients
AU - Ashok, Nipun
AU - Warad, Shivaraj
AU - Kalburgi, Nagaraj Balasaheb
AU - Bilichodmath, Shivaprasad
AU - Prabhakaran, Prabath Singh Valiyaparambil
AU - Tarakji, Bassel
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Aim: Periodontitis is a multifactorial disease, with microbial dental plaque as the primary etiological factor. However, the manifestation and progression of periodontitis is influenced by a wide variety of other determinants and factors such as social and behavioral factors, systemic factors, microbial composition of dental plaque, genetic, and many other emerging risk factors. The aim of this study was to analyze genetic polymorphisms in the toll-like receptor 9 (TLR9) gene at - 1237C/T and its association with chronic and generalized aggressive periodontitis (GAgP) in an Indian population.Materials and Methods: This study was carried out on 90 subjects, which included 30 GAgP and 30 chronic periodontitis patients and 30 healthy controls. Within the limitations of our study, only 30 subjects were included in each group due to the low prevalence of GAgP patients. Blood samples were drawn from the subjects and analyzed for TLR9 genetic polymorphism at - 1237C/T by using polymerase chain reaction-restriction fragment length polymorphism method.Results: No significant difference was found in genotype and allele frequency of TLR9 genetic polymorphism (- 1237C/T) in generalized aggressive and chronic periodontitis patients and healthy controls.Conclusion: Toll-like receptor 9 genetic polymorphism at - 1237C/T may not be associated with GAgP and chronic periodontitis patients in Indian population.
AB - Aim: Periodontitis is a multifactorial disease, with microbial dental plaque as the primary etiological factor. However, the manifestation and progression of periodontitis is influenced by a wide variety of other determinants and factors such as social and behavioral factors, systemic factors, microbial composition of dental plaque, genetic, and many other emerging risk factors. The aim of this study was to analyze genetic polymorphisms in the toll-like receptor 9 (TLR9) gene at - 1237C/T and its association with chronic and generalized aggressive periodontitis (GAgP) in an Indian population.Materials and Methods: This study was carried out on 90 subjects, which included 30 GAgP and 30 chronic periodontitis patients and 30 healthy controls. Within the limitations of our study, only 30 subjects were included in each group due to the low prevalence of GAgP patients. Blood samples were drawn from the subjects and analyzed for TLR9 genetic polymorphism at - 1237C/T by using polymerase chain reaction-restriction fragment length polymorphism method.Results: No significant difference was found in genotype and allele frequency of TLR9 genetic polymorphism (- 1237C/T) in generalized aggressive and chronic periodontitis patients and healthy controls.Conclusion: Toll-like receptor 9 genetic polymorphism at - 1237C/T may not be associated with GAgP and chronic periodontitis patients in Indian population.
KW - Aggressive periodontitis
KW - chronic periodontitis
KW - genetic polymorphism
KW - periodontal risk factor
KW - polymerase chain reaction
KW - toll-like receptor 9
UR - http://www.scopus.com/inward/record.url?scp=84920273434&partnerID=8YFLogxK
U2 - 10.4103/0972-124X.147407
DO - 10.4103/0972-124X.147407
M3 - Article
AN - SCOPUS:84920273434
SN - 0972-124X
VL - 18
SP - 723
EP - 727
JO - Journal of Indian Society of Periodontology
JF - Journal of Indian Society of Periodontology
IS - 6
ER -