TY - JOUR
T1 - The role of Interleukin-21 (IL-21) in allergic disorders
T2 - Biological insights and regulatory mechanisms
AU - Saadh, Mohamed J.
AU - Alfattah, Mohammed A.
AU - Ismail, Ahmed H.
AU - Saeed, Bashar Abdullah
AU - abbas, Huda hayder
AU - Elashmawy, Nabila F.
AU - hashim, Ghassan A.
AU - Ismail, Khatib Sayeed
AU - Abo-Zaid, Mabrouk A.
AU - Waggiallah, Hisham Ali
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/6/15
Y1 - 2024/6/15
N2 - In recent decades, allergic diseases subsequent from an IgE-mediated response to specific allergens have become a progressively public chronic disease worldwide. They have shaped an important medical and socio-economic burden. A significant proportion of allergic disorders are branded via a form 2 immune response relating Th2 cells, type 2 natural lymphoid cells, mast cells and eosinophils. Interleukin-21 (IL-21) is a participant of the type-I cytokine family manufactured through numerous subsets of stimulated CD4+ T cells and uses controlling properties on a diversity of immune cells. Increasingly, experimental sign suggests a character for IL-21 in the pathogenesis of numerous allergic disorders. The purpose of this review is to discuss the biological properties of IL-21 and to summaries current developments in its role in the regulation of allergic disorders.
AB - In recent decades, allergic diseases subsequent from an IgE-mediated response to specific allergens have become a progressively public chronic disease worldwide. They have shaped an important medical and socio-economic burden. A significant proportion of allergic disorders are branded via a form 2 immune response relating Th2 cells, type 2 natural lymphoid cells, mast cells and eosinophils. Interleukin-21 (IL-21) is a participant of the type-I cytokine family manufactured through numerous subsets of stimulated CD4+ T cells and uses controlling properties on a diversity of immune cells. Increasingly, experimental sign suggests a character for IL-21 in the pathogenesis of numerous allergic disorders. The purpose of this review is to discuss the biological properties of IL-21 and to summaries current developments in its role in the regulation of allergic disorders.
KW - Allergic diseases
KW - Asthma
KW - Cytokine
KW - IL-21
KW - Interleukin
UR - https://www.scopus.com/pages/publications/85192291983
U2 - 10.1016/j.intimp.2024.111825
DO - 10.1016/j.intimp.2024.111825
M3 - Review article
C2 - 38723368
AN - SCOPUS:85192291983
SN - 1567-5769
VL - 134
JO - International Immunopharmacology
JF - International Immunopharmacology
M1 - 111825
ER -
