Abstract
The present study was carried out to investigate the protective effect of vitamin C as antioxidant to reduce hepatotoxicity and spleen toxicity induced by lead. Lead acetate administered at 20 mg/kg intake caused severe alterations in liver and spleen manifested by hepatocytes degeneration and leucocytes infiltration and fibrosis in liver, ill-defined architecture and large macrophages in the spleen. Vitamin C administered at 500 mg/kg of vitamin C one hour prior to lead reduced hepatotoxicity but did not affect liver fibrosis. Moreover, Vitamin C reduced the toxicity in spleen characterized by well-defined spleen architecture.
| Original language | English |
|---|---|
| Pages (from-to) | 1425-1431 |
| Number of pages | 7 |
| Journal | Pakistan Journal of Zoology |
| Volume | 46 |
| Issue number | 5 |
| State | Published - 1 Oct 2014 |
| Externally published | Yes |
Keywords
- Lead
- Liver
- Mice-vitamin C
- Spleen
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