TY - JOUR
T1 - The long non-coding RNAs (lncRNA) in the pathogenesis of gastric cancer cells
T2 - molecular mechanisms and involvement miRNAs
AU - Saleh, Raed Obaid
AU - Al-Hawary, Sulieman Ibraheem Shelash
AU - Hammoud, Ahmad
AU - Hjazi, Ahmed
AU - Ayad Abdulrazzaq, Sumaya
AU - Rajput, Pranchal
AU - Alawsi, Taif
AU - Alnajar, Mohammed Jawad
AU - Alawadi, Ahmed
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature B.V. 2024.
PY - 2024/12
Y1 - 2024/12
N2 - A complex sequence of occurrences, including host genetic vulnerability, Helicobacter pylori infection, and other environmental variables, culminate in gastric cancer (GC). The development of several genetic and epigenetic changes in oncogenes and tumor suppressor genes causes dysregulation of several signaling pathways, which upsets the cell cycle and the equilibrium between cell division and apoptosis, leading to GC. Developments in computational biology and RNA-seq technology enable quick detection and characterization of long non-coding RNAs (lncRNAs). Recent studies have shown that long non-coding RNAs (lncRNAs) have multiple roles in the development of gastric cancer. These lncRNAs interact with molecules of protein, RNA, DNA, and/or combinations. This review article explores several gastric cancer-associated lncRNAs, such as ADAMTS9-AS2, UCA1, XBP-1, and LINC00152. These various lncRNAs could change GC cell apoptosis, migration, and invasion features in the tumor microenvironment. This review provides an overview of the most recent research on lncRNAs and GC cell apoptosis, migration, invasion, and drug resistance, focusing on studies conducted in cancer cells and healthy cells during differentiation.
AB - A complex sequence of occurrences, including host genetic vulnerability, Helicobacter pylori infection, and other environmental variables, culminate in gastric cancer (GC). The development of several genetic and epigenetic changes in oncogenes and tumor suppressor genes causes dysregulation of several signaling pathways, which upsets the cell cycle and the equilibrium between cell division and apoptosis, leading to GC. Developments in computational biology and RNA-seq technology enable quick detection and characterization of long non-coding RNAs (lncRNAs). Recent studies have shown that long non-coding RNAs (lncRNAs) have multiple roles in the development of gastric cancer. These lncRNAs interact with molecules of protein, RNA, DNA, and/or combinations. This review article explores several gastric cancer-associated lncRNAs, such as ADAMTS9-AS2, UCA1, XBP-1, and LINC00152. These various lncRNAs could change GC cell apoptosis, migration, and invasion features in the tumor microenvironment. This review provides an overview of the most recent research on lncRNAs and GC cell apoptosis, migration, invasion, and drug resistance, focusing on studies conducted in cancer cells and healthy cells during differentiation.
KW - Apoptosis
KW - Gastric cancer
KW - Invasion
KW - lncRNA
UR - https://www.scopus.com/pages/publications/85192069820
U2 - 10.1007/s11033-024-09546-x
DO - 10.1007/s11033-024-09546-x
M3 - Review article
C2 - 38704760
AN - SCOPUS:85192069820
SN - 0301-4851
VL - 51
JO - Molecular Biology Reports
JF - Molecular Biology Reports
IS - 1
M1 - 615
ER -
