The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA Damage

Huda H. Al-Khalaf; Peer Mohideen; Shreeram C. Nallar; Dhananjaya V. Kalvakolanu; Abdelilah Aboussekhra

doi:10.1074/jbc.M113.512640

The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA Damage

Huda H. Al-Khalaf
, Peer Mohideen
, Shreeram C. Nallar
, Dhananjaya V. Kalvakolanu
, Abdelilah Aboussekhra

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Background: The cyclin-dependent kinase inhibitor p16^INK4a is also a modulator of gene expression through an unknown mechanism. Results: p16^INK4a-CDK4 forms a heterocomplex with Sp1, which induces the expression and UV-dependent up-regulation of miR-141 and miR-146b-5p. Conclusion: p16^INK4a-CDK4 complex has transcriptional activity through interaction with the transcription factor Sp1. Significance: The microRNAs are novel effectors of the p16^INK4a-CDK4 complex.

Original language	English
Pages (from-to)	35511-35525
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	49
DOIs	https://doi.org/10.1074/jbc.M113.512640
State	Published - 6 Dec 2013
Externally published	Yes

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Al-Khalaf, H. H., Mohideen, P., Nallar, S. C., Kalvakolanu, D. V., & Aboussekhra, A. (2013). The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA Damage. Journal of Biological Chemistry, 288(49), 35511-35525. https://doi.org/10.1074/jbc.M113.512640

Al-Khalaf, Huda H. ; Mohideen, Peer ; Nallar, Shreeram C. et al. / The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA Damage. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 49. pp. 35511-35525.

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title = "The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA Damage",

abstract = "Background: The cyclin-dependent kinase inhibitor p16INK4a is also a modulator of gene expression through an unknown mechanism. Results: p16INK4a-CDK4 forms a heterocomplex with Sp1, which induces the expression and UV-dependent up-regulation of miR-141 and miR-146b-5p. Conclusion: p16INK4a-CDK4 complex has transcriptional activity through interaction with the transcription factor Sp1. Significance: The microRNAs are novel effectors of the p16INK4a-CDK4 complex.",

author = "Al-Khalaf, \{Huda H.\} and Peer Mohideen and Nallar, \{Shreeram C.\} and Kalvakolanu, \{Dhananjaya V.\} and Abdelilah Aboussekhra",

year = "2013",

month = dec,

day = "6",

doi = "10.1074/jbc.M113.512640",

language = "English",

volume = "288",

pages = "35511--35525",

journal = "Journal of Biological Chemistry",

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Al-Khalaf, HH, Mohideen, P, Nallar, SC, Kalvakolanu, DV & Aboussekhra, A 2013, 'The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA Damage', Journal of Biological Chemistry, vol. 288, no. 49, pp. 35511-35525. https://doi.org/10.1074/jbc.M113.512640

The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA Damage. / Al-Khalaf, Huda H.; Mohideen, Peer; Nallar, Shreeram C. et al.
In: Journal of Biological Chemistry, Vol. 288, No. 49, 06.12.2013, p. 35511-35525.

Research output: Contribution to journal › Article › peer-review

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T1 - The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA Damage

AU - Al-Khalaf, Huda H.

AU - Mohideen, Peer

AU - Nallar, Shreeram C.

AU - Kalvakolanu, Dhananjaya V.

AU - Aboussekhra, Abdelilah

PY - 2013/12/6

Y1 - 2013/12/6

N2 - Background: The cyclin-dependent kinase inhibitor p16INK4a is also a modulator of gene expression through an unknown mechanism. Results: p16INK4a-CDK4 forms a heterocomplex with Sp1, which induces the expression and UV-dependent up-regulation of miR-141 and miR-146b-5p. Conclusion: p16INK4a-CDK4 complex has transcriptional activity through interaction with the transcription factor Sp1. Significance: The microRNAs are novel effectors of the p16INK4a-CDK4 complex.

AB - Background: The cyclin-dependent kinase inhibitor p16INK4a is also a modulator of gene expression through an unknown mechanism. Results: p16INK4a-CDK4 forms a heterocomplex with Sp1, which induces the expression and UV-dependent up-regulation of miR-141 and miR-146b-5p. Conclusion: p16INK4a-CDK4 complex has transcriptional activity through interaction with the transcription factor Sp1. Significance: The microRNAs are novel effectors of the p16INK4a-CDK4 complex.

UR - https://www.scopus.com/pages/publications/84890296289

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SN - 0021-9258

VL - 288

SP - 35511

EP - 35525

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 49

ER -

Al-Khalaf HH, Mohideen P, Nallar SC, Kalvakolanu DV, Aboussekhra A. The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA Damage. Journal of Biological Chemistry. 2013 Dec 6;288(49):35511-35525. doi: 10.1074/jbc.M113.512640

The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA Damage

Abstract

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