The ameliorative effect of vinpocetine against gentamicin-induced uterine-injury in rats involves the inflammasome/caspase-1/IL-1β pathway

Ayman Geddawy, Mina Ezzat Attya, Abdel Rahman Hegazy, Mostafa Kamal AbdElhaseeb, Michael Atef Fawzy, Medhat Atta, Fatma F. Ali, Walaa Yehia Abdelzaher

Research output: Contribution to journalArticlepeer-review

Abstract

Background: There is limited data regarding the hazardous effect of gentamicin (GM) on the uterus and whether or not vinpocetine (Vinpo) ameliorates it. The present study aimed to identify the possible protective effect of Vinpo in GM-induced uterine injury in rats. Methods: Female rats were assorted in control-group, Vinpo-group, GM-group, and Vinpo plus GM group. Serum and uterine GM concentration were measured. Uterine oxidative stress parameters besides inflammatory and apoptotic biomarkers were evaluated. Uterine histopathological examination and interlukin-1beta (IL-1β) immune-histochemical study were detected. Results: GM significantly increased uterine oxidative stress, inflammatory and apoptotic biomarkers. Histopathological picture of uterine damage and increased IL-1β immunoexpression were detected. Vinpo significantly ameliorated the distributed GM concentration, oxidative stress, inflammatory and apoptotic biomarkers with a prompt improvement in histopathological picture and a decrease in IL-1β immunoexpression. Conclusion: Vinpo protective effect against GM-induced uterine injury involves modulation of inflammasome/caspase-1/IL-1β signaling pathway.

Original languageEnglish
Article number655
JournalMolecular Biology Reports
Volume51
Issue number1
DOIs
StatePublished - Dec 2024

Keywords

  • Caspase-1
  • Gentamicin
  • Inflammasome
  • Uterine injury
  • Vinpocetine

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