Synthesis, X-ray structure and in vitro cytotoxicity of trans-diammineplatinum(II) complexes of selenones, trans-[Pt(NH3)2(selenone)2](NO3)2

Ali Alhoshani; Adam A.A. Seliman; Ali Osman Altoum; Hatem A. Abuelizz; Saeed Ahmad; Muhammad Altaf; Khalid H. Omer; Manzar Sohail; Anvarhusein A. Isab

doi:10.1016/j.poly.2018.09.010

Synthesis, X-ray structure and in vitro cytotoxicity of trans-diammineplatinum(II) complexes of selenones, trans-[Pt(NH₃)₂(selenone)₂](NO₃)₂

Ali Alhoshani
, Adam A.A. Seliman
, Ali Osman Altoum
, Hatem A. Abuelizz
, Saeed Ahmad
, Muhammad Altaf
, Khalid H. Omer
, Manzar Sohail
, Anvarhusein A. Isab

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Seven trans platinum(II) complexes of selenones having the general formula, trans-[Pt(NH₃)₂(selenone)₂](NO₃)₂ have been synthesized and characterized using elemental analysis, IR, and NMR (¹H & ¹³C & ⁷⁷Se) spectroscopy. The crystal structure of one of them, trans-[Pt(NH₃)₂(PrImSe)₂](NO₃)₂ (5) was determined by single crystal X-ray diffraction analysis. The platinum atom in the complex cation adopts a distorted square planar geometry. The spectroscopic data particularly, a significant upfield shift in ⁷⁷Se NMR indicated the coordination of selenone ligands to platinum(II). The in vitro cytotoxicity of these complexes as well as of cisplatin was investigated using MTT assay against two human cancer cell lines, HeLa (cervical cancer cells) and MDA-231 (human breast cancer cells). The IC₅₀ values showed promising cytotoxicity for the prepared platinum(II) complexes, which in the case of 1, 4 and 6 is higher as compared to cisplatin.

Original language	English
Pages (from-to)	234-240
Number of pages	7
Journal	Polyhedron
Volume	158
DOIs	https://doi.org/10.1016/j.poly.2018.09.010
State	Published - 15 Jan 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Heterocyclic selenones
In vitro cytotoxicity
Transplatin
X-ray structure

Access to Document

10.1016/j.poly.2018.09.010

Cite this

@article{7daf9d0ef278494fb4a634f5975c155b,

title = "Synthesis, X-ray structure and in vitro cytotoxicity of trans-diammineplatinum(II) complexes of selenones, trans-[Pt(NH3)2(selenone)2](NO3)2",

abstract = "Seven trans platinum(II) complexes of selenones having the general formula, trans-[Pt(NH3)2(selenone)2](NO3)2 have been synthesized and characterized using elemental analysis, IR, and NMR (1H \& 13C \& 77Se) spectroscopy. The crystal structure of one of them, trans-[Pt(NH3)2(PrImSe)2](NO3)2 (5) was determined by single crystal X-ray diffraction analysis. The platinum atom in the complex cation adopts a distorted square planar geometry. The spectroscopic data particularly, a significant upfield shift in 77Se NMR indicated the coordination of selenone ligands to platinum(II). The in vitro cytotoxicity of these complexes as well as of cisplatin was investigated using MTT assay against two human cancer cell lines, HeLa (cervical cancer cells) and MDA-231 (human breast cancer cells). The IC50 values showed promising cytotoxicity for the prepared platinum(II) complexes, which in the case of 1, 4 and 6 is higher as compared to cisplatin.",

keywords = "Heterocyclic selenones, In vitro cytotoxicity, Transplatin, X-ray structure",

author = "Ali Alhoshani and Seliman, \{Adam A.A.\} and Altoum, \{Ali Osman\} and Abuelizz, \{Hatem A.\} and Saeed Ahmad and Muhammad Altaf and Omer, \{Khalid H.\} and Manzar Sohail and Isab, \{Anvarhusein A.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = jan,

day = "15",

doi = "10.1016/j.poly.2018.09.010",

language = "English",

volume = "158",

pages = "234--240",

journal = "Polyhedron",

issn = "0277-5387",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Synthesis, X-ray structure and in vitro cytotoxicity of trans-diammineplatinum(II) complexes of selenones, trans-[Pt(NH3)2(selenone)2](NO3)2

AU - Alhoshani, Ali

AU - Seliman, Adam A.A.

AU - Altoum, Ali Osman

AU - Abuelizz, Hatem A.

AU - Ahmad, Saeed

AU - Altaf, Muhammad

AU - Omer, Khalid H.

AU - Sohail, Manzar

AU - Isab, Anvarhusein A.

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Seven trans platinum(II) complexes of selenones having the general formula, trans-[Pt(NH3)2(selenone)2](NO3)2 have been synthesized and characterized using elemental analysis, IR, and NMR (1H & 13C & 77Se) spectroscopy. The crystal structure of one of them, trans-[Pt(NH3)2(PrImSe)2](NO3)2 (5) was determined by single crystal X-ray diffraction analysis. The platinum atom in the complex cation adopts a distorted square planar geometry. The spectroscopic data particularly, a significant upfield shift in 77Se NMR indicated the coordination of selenone ligands to platinum(II). The in vitro cytotoxicity of these complexes as well as of cisplatin was investigated using MTT assay against two human cancer cell lines, HeLa (cervical cancer cells) and MDA-231 (human breast cancer cells). The IC50 values showed promising cytotoxicity for the prepared platinum(II) complexes, which in the case of 1, 4 and 6 is higher as compared to cisplatin.

AB - Seven trans platinum(II) complexes of selenones having the general formula, trans-[Pt(NH3)2(selenone)2](NO3)2 have been synthesized and characterized using elemental analysis, IR, and NMR (1H & 13C & 77Se) spectroscopy. The crystal structure of one of them, trans-[Pt(NH3)2(PrImSe)2](NO3)2 (5) was determined by single crystal X-ray diffraction analysis. The platinum atom in the complex cation adopts a distorted square planar geometry. The spectroscopic data particularly, a significant upfield shift in 77Se NMR indicated the coordination of selenone ligands to platinum(II). The in vitro cytotoxicity of these complexes as well as of cisplatin was investigated using MTT assay against two human cancer cell lines, HeLa (cervical cancer cells) and MDA-231 (human breast cancer cells). The IC50 values showed promising cytotoxicity for the prepared platinum(II) complexes, which in the case of 1, 4 and 6 is higher as compared to cisplatin.

KW - Heterocyclic selenones

KW - In vitro cytotoxicity

KW - Transplatin

KW - X-ray structure

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DO - 10.1016/j.poly.2018.09.010

M3 - Article

AN - SCOPUS:85056700370

SN - 0277-5387

VL - 158

SP - 234

EP - 240

JO - Polyhedron

JF - Polyhedron

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