Synthesis, Spectral Characterization, In Vitro Antibacterial Evaluation and POM Analyses of Palladium(II) Thiocyanate Complexes of Thioamides

Shafqat Nadeem; Muhammad Sirajuddin; Saeed Ahmad; Sadaf Yaqub; Muhammad Irshad Ali; Syed Ahmed Tirmizi; Saqib Ali; Abdul Hameed

doi:10.1007/s11094-017-1695-z

Synthesis, Spectral Characterization, In Vitro Antibacterial Evaluation and POM Analyses of Palladium(II) Thiocyanate Complexes of Thioamides

Shafqat Nadeem
, Muhammad Sirajuddin
, Saeed Ahmad
, Sadaf Yaqub
, Muhammad Irshad Ali
, Syed Ahmed Tirmizi
, Saqib Ali
, Abdul Hameed

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Palladium(II) thiocyanate complexes of general formula, [PdL₄](SCN)₂, where L = thiourea (Tu), N-methylthiourea (Metu), N,N-dimethylthiourea (Dmtu), tetramethylthiourea (Tmtu), imidazolidine-2-thione (Imt) and thionicotinamide (Tna) were prepared by the reaction of K₂[PdCl₄] with thioamides followed by the addition of Potassium thiocyanate in 1:2:2 molar ratio. The complexes were characterized by elemental analysis, and spectroscopic techniques (IR, ¹H and ¹³C NMR), and were screened for antibacterial activities against four strains of bacteria {Staphylococcus aureus (ATCC 25923), Bacillus subtilis (DSM 3256), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 10197)}. Some of the compounds exhibited signifiacnt antibacterial activity even higher than the standards showing the potential for their use as potent antibacterial agents. POM analyses reveal that the compounds are slightly toxic. Moreover, they have 8 ~ 12 % drug score, which is an important parameter for a compound possessing the drug properties.

Original language	English
Pages (from-to)	793-799
Number of pages	7
Journal	Pharmaceutical Chemistry Journal
Volume	51
Issue number	9
DOIs	https://doi.org/10.1007/s11094-017-1695-z
State	Published - 1 Dec 2017
Externally published	Yes

Keywords

antibacterial activity
palladium(II) complexes
POM analysis
thioamide
thiocyanate

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10.1007/s11094-017-1695-z

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title = "Synthesis, Spectral Characterization, In Vitro Antibacterial Evaluation and POM Analyses of Palladium(II) Thiocyanate Complexes of Thioamides",

abstract = "Palladium(II) thiocyanate complexes of general formula, [PdL4](SCN)2, where L = thiourea (Tu), N-methylthiourea (Metu), N,N-dimethylthiourea (Dmtu), tetramethylthiourea (Tmtu), imidazolidine-2-thione (Imt) and thionicotinamide (Tna) were prepared by the reaction of K2[PdCl4] with thioamides followed by the addition of Potassium thiocyanate in 1:2:2 molar ratio. The complexes were characterized by elemental analysis, and spectroscopic techniques (IR, 1H and 13C NMR), and were screened for antibacterial activities against four strains of bacteria \{Staphylococcus aureus (ATCC 25923), Bacillus subtilis (DSM 3256), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 10197)\}. Some of the compounds exhibited signifiacnt antibacterial activity even higher than the standards showing the potential for their use as potent antibacterial agents. POM analyses reveal that the compounds are slightly toxic. Moreover, they have 8 \textasciitilde{} 12 \% drug score, which is an important parameter for a compound possessing the drug properties.",

keywords = "antibacterial activity, palladium(II) complexes, POM analysis, thioamide, thiocyanate",

author = "Shafqat Nadeem and Muhammad Sirajuddin and Saeed Ahmad and Sadaf Yaqub and Ali, \{Muhammad Irshad\} and Tirmizi, \{Syed Ahmed\} and Saqib Ali and Abdul Hameed",

note = "Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2017",

month = dec,

day = "1",

doi = "10.1007/s11094-017-1695-z",

language = "English",

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journal = "Pharmaceutical Chemistry Journal",

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TY - JOUR

T1 - Synthesis, Spectral Characterization, In Vitro Antibacterial Evaluation and POM Analyses of Palladium(II) Thiocyanate Complexes of Thioamides

AU - Nadeem, Shafqat

AU - Sirajuddin, Muhammad

AU - Ahmad, Saeed

AU - Yaqub, Sadaf

AU - Ali, Muhammad Irshad

AU - Tirmizi, Syed Ahmed

AU - Ali, Saqib

AU - Hameed, Abdul

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Palladium(II) thiocyanate complexes of general formula, [PdL4](SCN)2, where L = thiourea (Tu), N-methylthiourea (Metu), N,N-dimethylthiourea (Dmtu), tetramethylthiourea (Tmtu), imidazolidine-2-thione (Imt) and thionicotinamide (Tna) were prepared by the reaction of K2[PdCl4] with thioamides followed by the addition of Potassium thiocyanate in 1:2:2 molar ratio. The complexes were characterized by elemental analysis, and spectroscopic techniques (IR, 1H and 13C NMR), and were screened for antibacterial activities against four strains of bacteria {Staphylococcus aureus (ATCC 25923), Bacillus subtilis (DSM 3256), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 10197)}. Some of the compounds exhibited signifiacnt antibacterial activity even higher than the standards showing the potential for their use as potent antibacterial agents. POM analyses reveal that the compounds are slightly toxic. Moreover, they have 8 ~ 12 % drug score, which is an important parameter for a compound possessing the drug properties.

AB - Palladium(II) thiocyanate complexes of general formula, [PdL4](SCN)2, where L = thiourea (Tu), N-methylthiourea (Metu), N,N-dimethylthiourea (Dmtu), tetramethylthiourea (Tmtu), imidazolidine-2-thione (Imt) and thionicotinamide (Tna) were prepared by the reaction of K2[PdCl4] with thioamides followed by the addition of Potassium thiocyanate in 1:2:2 molar ratio. The complexes were characterized by elemental analysis, and spectroscopic techniques (IR, 1H and 13C NMR), and were screened for antibacterial activities against four strains of bacteria {Staphylococcus aureus (ATCC 25923), Bacillus subtilis (DSM 3256), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 10197)}. Some of the compounds exhibited signifiacnt antibacterial activity even higher than the standards showing the potential for their use as potent antibacterial agents. POM analyses reveal that the compounds are slightly toxic. Moreover, they have 8 ~ 12 % drug score, which is an important parameter for a compound possessing the drug properties.

KW - antibacterial activity

KW - palladium(II) complexes

KW - POM analysis

KW - thioamide

KW - thiocyanate

UR - https://www.scopus.com/pages/publications/85016604551

U2 - 10.1007/s11094-017-1695-z

DO - 10.1007/s11094-017-1695-z

M3 - Article

AN - SCOPUS:85016604551

SN - 0091-150X

VL - 51

SP - 793

EP - 799

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

IS - 9

ER -

Synthesis, Spectral Characterization, In Vitro Antibacterial Evaluation and POM Analyses of Palladium(II) Thiocyanate Complexes of Thioamides

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Keywords

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