Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening

Ahmed M. Alafeefy; Adel S. El-Azab; Menshawy A. Mohamed; Mohamed Afroz Bakhat; S. G. Abdel-Hamid

doi:10.1016/j.jscs.2011.07.005

Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening

Ahmed M. Alafeefy
, Adel S. El-Azab
, Menshawy A. Mohamed
, Mohamed Afroz Bakhat
, S. G. Abdel-Hamid

Pharmaceutical Chemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles, 1,2,4-triazino[3,4-c]quinazoline, benzimidazo[1,2-c]quinazoline and quinazoline-bearing thiazolidinone moiety proved to contribute for antimicrobial activity. The detailed synthesis and their antimicrobial screening are reported.

Original language	English
Pages (from-to)	319-325
Number of pages	7
Journal	Journal of Saudi Chemical Society
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.jscs.2011.07.005
State	Published - Oct 2011

Keywords

6-Iodo-2-thienylquinazolin-4(3H)-one
Antimicrobial screening
Synthesis

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10.1016/j.jscs.2011.07.005

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title = "Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening",

abstract = "A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles, 1,2,4-triazino[3,4-c]quinazoline, benzimidazo[1,2-c]quinazoline and quinazoline-bearing thiazolidinone moiety proved to contribute for antimicrobial activity. The detailed synthesis and their antimicrobial screening are reported.",

keywords = "6-Iodo-2-thienylquinazolin-4(3H)-one, Antimicrobial screening, Synthesis",

author = "Alafeefy, \{Ahmed M.\} and El-Azab, \{Adel S.\} and Mohamed, \{Menshawy A.\} and Bakhat, \{Mohamed Afroz\} and Abdel-Hamid, \{S. G.\}",

year = "2011",

month = oct,

doi = "10.1016/j.jscs.2011.07.005",

language = "English",

volume = "15",

pages = "319--325",

journal = "Journal of Saudi Chemical Society",

issn = "1319-6103",

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TY - JOUR

T1 - Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening

AU - Alafeefy, Ahmed M.

AU - El-Azab, Adel S.

AU - Mohamed, Menshawy A.

AU - Bakhat, Mohamed Afroz

AU - Abdel-Hamid, S. G.

PY - 2011/10

Y1 - 2011/10

N2 - A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles, 1,2,4-triazino[3,4-c]quinazoline, benzimidazo[1,2-c]quinazoline and quinazoline-bearing thiazolidinone moiety proved to contribute for antimicrobial activity. The detailed synthesis and their antimicrobial screening are reported.

AB - A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles, 1,2,4-triazino[3,4-c]quinazoline, benzimidazo[1,2-c]quinazoline and quinazoline-bearing thiazolidinone moiety proved to contribute for antimicrobial activity. The detailed synthesis and their antimicrobial screening are reported.

KW - 6-Iodo-2-thienylquinazolin-4(3H)-one

KW - Antimicrobial screening

KW - Synthesis

UR - https://www.scopus.com/pages/publications/80955142737

U2 - 10.1016/j.jscs.2011.07.005

DO - 10.1016/j.jscs.2011.07.005

M3 - Article

AN - SCOPUS:80955142737

SN - 1319-6103

VL - 15

SP - 319

EP - 325

JO - Journal of Saudi Chemical Society

JF - Journal of Saudi Chemical Society

IS - 4

ER -

Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening

Abstract

Keywords

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