TY - JOUR
T1 - Synthesis of new chromeno[4,3-b]pyrazolo[4,3-e]pyridines derivatives with antimicrobial evaluation
AU - El-Essawy, Farag A.
AU - El-Etrawy, Abd Allah Sh
PY - 2014/1
Y1 - 2014/1
N2 - A series of 2-oxo-2,5-dihydro-1H-chromeno[4,3-b]pyridine derivatives were obtained by using a one-pot three component reaction of 2,2-disubstituted chroman-4-one with aromatic aldehydes and 2-cyanoacetamide in the presence of sodium hydroxide under solvent-free conditions. Heating chromenopyridine derivatives with phosphoryl chloride gave the corresponding chloro derivatives. The reaction of the chloro derivatives with hydrazine hydrate afforded dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridines derivatives. Condensation of the dimethyl derivative compound with the aromatic aldehydes gave 8-Arylideneamino-6,6-dimethyl-10H-chromeno[4,3-b]pyrazolo[4,3-e]pyridine.
AB - A series of 2-oxo-2,5-dihydro-1H-chromeno[4,3-b]pyridine derivatives were obtained by using a one-pot three component reaction of 2,2-disubstituted chroman-4-one with aromatic aldehydes and 2-cyanoacetamide in the presence of sodium hydroxide under solvent-free conditions. Heating chromenopyridine derivatives with phosphoryl chloride gave the corresponding chloro derivatives. The reaction of the chloro derivatives with hydrazine hydrate afforded dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridines derivatives. Condensation of the dimethyl derivative compound with the aromatic aldehydes gave 8-Arylideneamino-6,6-dimethyl-10H-chromeno[4,3-b]pyrazolo[4,3-e]pyridine.
UR - https://www.scopus.com/pages/publications/84894900400
U2 - 10.1002/jhet.1687
DO - 10.1002/jhet.1687
M3 - Article
AN - SCOPUS:84894900400
SN - 0022-152X
VL - 51
SP - 191
EP - 195
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 1
ER -