TY - JOUR
T1 - Synthesis of new cadmium(II) complexes of Schiff bases as alkaline phosphatase inhibitors and their antimicrobial activity
AU - Irfan, Rana Muhammad
AU - Shaheen, Muhammad Ashraf
AU - Saleem, Muhammad
AU - Tahir, Muhammad Nawaz
AU - Munawar, Khurram Shahzad
AU - Ahmad, Saeed
AU - Rubab, Syeda Laila
AU - Tahir, Tehreem
AU - Kotwica-Mojzych, Katarzyna
AU - Mojzych, Mariusz
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/10
Y1 - 2021/10
N2 - The present investigation deals with the synthesis, characterization and pharmacological evaluation of four cadmium complexes (1–4) with Schiff bases (1L-4L) derived from the substituted amines and aryl aldehydes. Amantadine is reacted with different aryl aldehydes (salicylaldehyde, 3-ethoxysalicylaldehyde and 4-(diethylamino) salicylaldehyde) to prepare Schiff base ligands 1L-3L, while 4L was prepared using 4-methylaniline. The complexes were characterized by elemental analysis, spectroscopic techniques and thermal analysis, and the structure of one of the ligands, 3L was determined by X-ray crystallography. The spectroscopic data indicate that the ligands coordinate with Cd(II) in a bidentate fashion to give octahedral geometry. Single crystal XRD analysis shows that 3L is orthorhombic with the space group P212121. The ligands and their Cd(II) complexes were evaluated for antimicrobial activities, while the complexes were also investigated for inhibition effects towards an enzyme, alkaline phosphatase. The anti-microbial screening results showed that cadmium complex 1 exhibited significant antibacterial potential, particularly against Staphylococcus aureus with respect to the corresponding ligand suggesting that the complexes are more effective than their ligands for antimicrobial activity. In case of alkaline phosphatase inhibition screening, the synthesized cadmium complex 1 was found to maximally inhibit the activity of alkaline phosphatase in comparison to rest of three complexes.
AB - The present investigation deals with the synthesis, characterization and pharmacological evaluation of four cadmium complexes (1–4) with Schiff bases (1L-4L) derived from the substituted amines and aryl aldehydes. Amantadine is reacted with different aryl aldehydes (salicylaldehyde, 3-ethoxysalicylaldehyde and 4-(diethylamino) salicylaldehyde) to prepare Schiff base ligands 1L-3L, while 4L was prepared using 4-methylaniline. The complexes were characterized by elemental analysis, spectroscopic techniques and thermal analysis, and the structure of one of the ligands, 3L was determined by X-ray crystallography. The spectroscopic data indicate that the ligands coordinate with Cd(II) in a bidentate fashion to give octahedral geometry. Single crystal XRD analysis shows that 3L is orthorhombic with the space group P212121. The ligands and their Cd(II) complexes were evaluated for antimicrobial activities, while the complexes were also investigated for inhibition effects towards an enzyme, alkaline phosphatase. The anti-microbial screening results showed that cadmium complex 1 exhibited significant antibacterial potential, particularly against Staphylococcus aureus with respect to the corresponding ligand suggesting that the complexes are more effective than their ligands for antimicrobial activity. In case of alkaline phosphatase inhibition screening, the synthesized cadmium complex 1 was found to maximally inhibit the activity of alkaline phosphatase in comparison to rest of three complexes.
KW - Alkaline phosphatase inhibition
KW - Antimicrobial studies
KW - Cadmium complexes
KW - Schiff bases
UR - https://www.scopus.com/pages/publications/85111478167
U2 - 10.1016/j.arabjc.2021.103308
DO - 10.1016/j.arabjc.2021.103308
M3 - Article
AN - SCOPUS:85111478167
SN - 1878-5352
VL - 14
JO - Arabian Journal of Chemistry
JF - Arabian Journal of Chemistry
IS - 10
M1 - 103308
ER -