Synthesis of new bis-phthalimide and thalidomide ester derivatives, and evaluation of their cytotoxic activity

Amany Mostafa Ahmed Osman; Eman Abdel Hamid Mansour; Magdy Abdel Hamid Zahran; Erik B. Pedersen

Synthesis of new bis-phthalimide and thalidomide ester derivatives, and evaluation of their cytotoxic activity

Amany Mostafa Ahmed Osman
, Eman Abdel Hamid Mansour
, Magdy Abdel Hamid Zahran
, Erik B. Pedersen

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The esterification reaction of trimellitic anhydride chloride TMAC 1 with N-(hydroxymethyl) phthalimide NHMP 2, N-(2-hydroxyethyl) phthalimide NHEP 3 or N-(hydroxymethyl) thalidomide NHMT 4 afforded novel cyclic imide-ester derivatives; phthaloyl-phthalic anhydride methyl ester PPAME 5, phthaloyl-phthalic anhydride ethyl ester PPAEE 6 and thalidomide-phthalic anhydride methyl ester TPAME 7, respectively. These novel derivatives appeared very useful to prepare number of new hybrid structure of substituted N, Nbis-phthalimide and phthalimide-thalidomide moieties with different amino acids. The cytotoxicity of all synthesized compounds were in vitro evaluated against Hep-G2 and MCF-7, which showed that phthalimide derivatives 6, 9b, 10d, 11 and 12 possess significant antitumor potency.

Original language	English
Article number	32
Pages (from-to)	158-165
Number of pages	8
Journal	International Journal of Pharmaceutical Sciences Review and Research
Volume	33
Issue number	2
State	Published - 1 Jul 2015
Externally published	Yes

Keywords

Amino acids
Antitumor
Cytotoxicity
Phthalimide
Thalidomide

Cite this

@article{6a91a9cbe1ef46dd885a7db2899f9c56,

title = "Synthesis of new bis-phthalimide and thalidomide ester derivatives, and evaluation of their cytotoxic activity",

abstract = "The esterification reaction of trimellitic anhydride chloride TMAC 1 with N-(hydroxymethyl) phthalimide NHMP 2, N-(2-hydroxyethyl) phthalimide NHEP 3 or N-(hydroxymethyl) thalidomide NHMT 4 afforded novel cyclic imide-ester derivatives; phthaloyl-phthalic anhydride methyl ester PPAME 5, phthaloyl-phthalic anhydride ethyl ester PPAEE 6 and thalidomide-phthalic anhydride methyl ester TPAME 7, respectively. These novel derivatives appeared very useful to prepare number of new hybrid structure of substituted N, Nbis-phthalimide and phthalimide-thalidomide moieties with different amino acids. The cytotoxicity of all synthesized compounds were in vitro evaluated against Hep-G2 and MCF-7, which showed that phthalimide derivatives 6, 9b, 10d, 11 and 12 possess significant antitumor potency.",

keywords = "Amino acids, Antitumor, Cytotoxicity, Phthalimide, Thalidomide",

author = "Osman, \{Amany Mostafa Ahmed\} and Mansour, \{Eman Abdel Hamid\} and Zahran, \{Magdy Abdel Hamid\} and Pedersen, \{Erik B.\}",

year = "2015",

month = jul,

day = "1",

language = "English",

volume = "33",

pages = "158--165",

journal = "International Journal of Pharmaceutical Sciences Review and Research",

issn = "0976-044X",

publisher = "Global Research Online",

number = "2",

}

Synthesis of new bis-phthalimide and thalidomide ester derivatives, and evaluation of their cytotoxic activity. / Osman, Amany Mostafa Ahmed; Mansour, Eman Abdel Hamid; Zahran, Magdy Abdel Hamid et al.
In: International Journal of Pharmaceutical Sciences Review and Research, Vol. 33, No. 2, 32, 01.07.2015, p. 158-165.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of new bis-phthalimide and thalidomide ester derivatives, and evaluation of their cytotoxic activity

AU - Osman, Amany Mostafa Ahmed

AU - Mansour, Eman Abdel Hamid

AU - Zahran, Magdy Abdel Hamid

AU - Pedersen, Erik B.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - The esterification reaction of trimellitic anhydride chloride TMAC 1 with N-(hydroxymethyl) phthalimide NHMP 2, N-(2-hydroxyethyl) phthalimide NHEP 3 or N-(hydroxymethyl) thalidomide NHMT 4 afforded novel cyclic imide-ester derivatives; phthaloyl-phthalic anhydride methyl ester PPAME 5, phthaloyl-phthalic anhydride ethyl ester PPAEE 6 and thalidomide-phthalic anhydride methyl ester TPAME 7, respectively. These novel derivatives appeared very useful to prepare number of new hybrid structure of substituted N, Nbis-phthalimide and phthalimide-thalidomide moieties with different amino acids. The cytotoxicity of all synthesized compounds were in vitro evaluated against Hep-G2 and MCF-7, which showed that phthalimide derivatives 6, 9b, 10d, 11 and 12 possess significant antitumor potency.

AB - The esterification reaction of trimellitic anhydride chloride TMAC 1 with N-(hydroxymethyl) phthalimide NHMP 2, N-(2-hydroxyethyl) phthalimide NHEP 3 or N-(hydroxymethyl) thalidomide NHMT 4 afforded novel cyclic imide-ester derivatives; phthaloyl-phthalic anhydride methyl ester PPAME 5, phthaloyl-phthalic anhydride ethyl ester PPAEE 6 and thalidomide-phthalic anhydride methyl ester TPAME 7, respectively. These novel derivatives appeared very useful to prepare number of new hybrid structure of substituted N, Nbis-phthalimide and phthalimide-thalidomide moieties with different amino acids. The cytotoxicity of all synthesized compounds were in vitro evaluated against Hep-G2 and MCF-7, which showed that phthalimide derivatives 6, 9b, 10d, 11 and 12 possess significant antitumor potency.

KW - Amino acids

KW - Antitumor

KW - Cytotoxicity

KW - Phthalimide

KW - Thalidomide

UR - https://www.scopus.com/pages/publications/84940515112

M3 - Article

AN - SCOPUS:84940515112

SN - 0976-044X

VL - 33

SP - 158

EP - 165

JO - International Journal of Pharmaceutical Sciences Review and Research

JF - International Journal of Pharmaceutical Sciences Review and Research

IS - 2

M1 - 32

ER -

Synthesis of new bis-phthalimide and thalidomide ester derivatives, and evaluation of their cytotoxic activity

Abstract

Keywords

Other files and links

Fingerprint

Cite this