Synthesis of new 1,3,4-oxadiazol, thiadiazole, 1,2,4-triazole, and arylidene hydrazide derivatives of 4-oxo-1,4-dihydroquinoline with antimicrobial evaluation

A series of substituted 1,3,4-oxadiazole, 1,2,4-triazole, and 1,3,4-thiadiazole derivatives of the substituted 3-carboethoxy-1,4-dihydro-4- oxoquinoline have been synthesized through the reaction of the key intermediate thiosemicarbazide derivatives with different reagents. N′-Arylidene-4-oxo- 1,4-dihydroquinoline-3-carbohydrazides were also synthesized through the condensation reaction of the corresponding hydrazides with the appropriate aldehydes. Antimicrobial activity of some of the synthesized compounds was evaluated.