TY - JOUR
T1 - Synthesis of important new pyrrolo[3,4-c]pyrazoles and pyrazolyl-pyrrolines from heterocyclic β-ketonitriles
AU - Amer, Fathy Abdel Kader
AU - Hammouda, Metwally
AU - El-Ahl, Abdel Aziz Sayed
AU - Abdel-Wahab, Bakr Fathy
PY - 2007
Y1 - 2007
N2 - Treatment of heterocyclic β-ketonitriles 1a,b with hydrazine hydrate and phenylhydrazine afforded the hydrazine derivatives 2a-d which cyclized in PPAinto pyrrolo[3,4-c]pyrazoles 3a-d. Reaction of 1a,b with cyanoacetohydrazide furnished the cyanoacetyl pyrrolo[3,4-c]pyrazoles 4a,b. The hydrazine 2c reacted with β-diketone and β-ketoesters to afford pyrazolyl-pyrrolines 5-7. Also the later hydrazine reacted with some D-aldoses and aceteophenone to give the corresponding hydrazones 10-12 and hydrazine carboxamide derivatives 15a,b respectively.
AB - Treatment of heterocyclic β-ketonitriles 1a,b with hydrazine hydrate and phenylhydrazine afforded the hydrazine derivatives 2a-d which cyclized in PPAinto pyrrolo[3,4-c]pyrazoles 3a-d. Reaction of 1a,b with cyanoacetohydrazide furnished the cyanoacetyl pyrrolo[3,4-c]pyrazoles 4a,b. The hydrazine 2c reacted with β-diketone and β-ketoesters to afford pyrazolyl-pyrrolines 5-7. Also the later hydrazine reacted with some D-aldoses and aceteophenone to give the corresponding hydrazones 10-12 and hydrazine carboxamide derivatives 15a,b respectively.
KW - 3-pyrrolidinone
KW - Aceteophenone
KW - Acetylacetone
KW - D-aldoses
KW - Ethyl acetoacetate
KW - Hydrazine
KW - Pyrrolo[3,4-c]pyrazole
UR - https://www.scopus.com/pages/publications/38349049648
U2 - 10.1002/jccs.200700217
DO - 10.1002/jccs.200700217
M3 - Article
AN - SCOPUS:38349049648
SN - 0009-4536
VL - 54
SP - 1543
EP - 1552
JO - Journal of the Chinese Chemical Society
JF - Journal of the Chinese Chemical Society
IS - 6
ER -