Synthesis of 2,5-bis(2′-piperidylmethyl) piperidine and related compounds

Metwally Hammouda; Ez el Din Kandeel; Wafaa Hamama; Elsayed Afsah

doi:10.1007/BF02974131

Synthesis of 2,5-bis(2′-piperidylmethyl) piperidine and related compounds

Metwally Hammouda
, Ez el Din Kandeel
, Wafaa Hamama
, Elsayed Afsah

Mansoura University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The triketones 3–6 were obtained by alkylation of cyclopentanone or cyclohexanone with the appropriate cycloalkanone bis-Mannich base (1) or (2). Schmidt reaction of the tricketones 3–6 afforded the corresponding tricyclic lactames 7–10 respectively. Reduction of 7 and 9 gave compounds 11 and 12 respectively.

Original language	English
Pages (from-to)	68-70
Number of pages	3
Journal	Archives of Pharmacal Research
Volume	16
Issue number	1
DOIs	https://doi.org/10.1007/BF02974131
State	Published - Mar 1993
Externally published	Yes

Keywords

Bis(piperidinomethyl)piperidine
Nitrogen heterocycles
Tricyclic lactames
Tricyclic-triketones

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10.1007/BF02974131

Cite this

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title = "Synthesis of 2,5-bis(2′-piperidylmethyl) piperidine and related compounds",

abstract = "The triketones 3–6 were obtained by alkylation of cyclopentanone or cyclohexanone with the appropriate cycloalkanone bis-Mannich base (1) or (2). Schmidt reaction of the tricketones 3–6 afforded the corresponding tricyclic lactames 7–10 respectively. Reduction of 7 and 9 gave compounds 11 and 12 respectively.",

keywords = "Bis(piperidinomethyl)piperidine, Nitrogen heterocycles, Tricyclic lactames, Tricyclic-triketones",

author = "Metwally Hammouda and Kandeel, \{Ez el Din\} and Wafaa Hamama and Elsayed Afsah",

year = "1993",

month = mar,

doi = "10.1007/BF02974131",

language = "English",

volume = "16",

pages = "68--70",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

number = "1",

}

TY - JOUR

T1 - Synthesis of 2,5-bis(2′-piperidylmethyl) piperidine and related compounds

AU - Hammouda, Metwally

AU - Kandeel, Ez el Din

AU - Hamama, Wafaa

AU - Afsah, Elsayed

PY - 1993/3

Y1 - 1993/3

N2 - The triketones 3–6 were obtained by alkylation of cyclopentanone or cyclohexanone with the appropriate cycloalkanone bis-Mannich base (1) or (2). Schmidt reaction of the tricketones 3–6 afforded the corresponding tricyclic lactames 7–10 respectively. Reduction of 7 and 9 gave compounds 11 and 12 respectively.

AB - The triketones 3–6 were obtained by alkylation of cyclopentanone or cyclohexanone with the appropriate cycloalkanone bis-Mannich base (1) or (2). Schmidt reaction of the tricketones 3–6 afforded the corresponding tricyclic lactames 7–10 respectively. Reduction of 7 and 9 gave compounds 11 and 12 respectively.

KW - Bis(piperidinomethyl)piperidine

KW - Nitrogen heterocycles

KW - Tricyclic lactames

KW - Tricyclic-triketones

UR - https://www.scopus.com/pages/publications/0027244730

U2 - 10.1007/BF02974131

DO - 10.1007/BF02974131

M3 - Article

AN - SCOPUS:0027244730

SN - 0253-6269

VL - 16

SP - 68

EP - 70

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 1

ER -

Synthesis of 2,5-bis(2′-piperidylmethyl) piperidine and related compounds

Abstract

Keywords

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