Synthesis, crystal structure and anticancer activity of tetrakis(N-isopropylimidazolidine-2-selenone)platinum(II) chloride

Saeed Ahmad; Ali Osman S. Altoum; Ján Vančo; Radka Křikavová; Zdeněk Trávníček; Zdeněk Dvořák; Muhammad Altaf; Manzar Sohail; Anvarhusein A. Isab

doi:10.1016/j.molstruc.2017.09.068

Synthesis, crystal structure and anticancer activity of tetrakis(N-isopropylimidazolidine-2-selenone)platinum(II) chloride

Saeed Ahmad
, Ali Osman S. Altoum
, Ján Vančo
, Radka Křikavová
, Zdeněk Trávníček
, Zdeněk Dvořák
, Muhammad Altaf
, Manzar Sohail
, Anvarhusein A. Isab

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A Platinum(II) complex of N-isopropylimidazolidine-2-selenone (i-PrImSe), [Pt(i-PrImSe)₄]Cl₂ (1) was prepared and characterized by elemental analysis, IR and NMR (¹H, ¹³C, ⁷⁷Se & ¹⁹⁵Pt) spectroscopy, and X-ray crystallography. The structure of 1 consists of [Pt(i-PrImSe)₄]²⁺ complex ion and chloride counter ions. The platinum(II) atom adopts a distorted square planar geometry. The in vitro antitumor activity of 1 as well as cisplatin, was evaluated by MTT assay against human; ovarian carcinoma A2780 and its cisplatin-resistant subline A2780R, prostate cancer 22Rv1 and breast cancer MCF-7 cell lines. The title complex displayed the activity against the A2780 cells (IC₅₀ = 30.8 μM) at the level comparable to cisplatin (IC₅₀ = 26.8 μM). The interaction studies with sulfur-containing biomolecules revealed its ability to form a variety of intermediates and oxidized species with L-cysteine and reduced glutathione.

Original language	English
Pages (from-to)	232-236
Number of pages	5
Journal	Journal of Molecular Structure
Volume	1152
DOIs	https://doi.org/10.1016/j.molstruc.2017.09.068
State	Published - 15 Jan 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer activity
Cisplatin
N-Isopropylimidazolidine-2-selenone
Platinum(II) complex
X-ray structure

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10.1016/j.molstruc.2017.09.068

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@article{965af2989c6e4406b443cc2eb4116a69,

title = "Synthesis, crystal structure and anticancer activity of tetrakis(N-isopropylimidazolidine-2-selenone)platinum(II) chloride",

abstract = "A Platinum(II) complex of N-isopropylimidazolidine-2-selenone (i-PrImSe), [Pt(i-PrImSe)4]Cl2 (1) was prepared and characterized by elemental analysis, IR and NMR (1H, 13C, 77Se \& 195Pt) spectroscopy, and X-ray crystallography. The structure of 1 consists of [Pt(i-PrImSe)4]2+ complex ion and chloride counter ions. The platinum(II) atom adopts a distorted square planar geometry. The in vitro antitumor activity of 1 as well as cisplatin, was evaluated by MTT assay against human; ovarian carcinoma A2780 and its cisplatin-resistant subline A2780R, prostate cancer 22Rv1 and breast cancer MCF-7 cell lines. The title complex displayed the activity against the A2780 cells (IC50 = 30.8 μM) at the level comparable to cisplatin (IC50 = 26.8 μM). The interaction studies with sulfur-containing biomolecules revealed its ability to form a variety of intermediates and oxidized species with L-cysteine and reduced glutathione.",

keywords = "Anticancer activity, Cisplatin, N-Isopropylimidazolidine-2-selenone, Platinum(II) complex, X-ray structure",

author = "Saeed Ahmad and Altoum, \{Ali Osman S.\} and J{\'a}n Van{\v c}o and Radka K{\v r}ikavov{\'a} and Zden{\v e}k Tr{\'a}vn{\'i}{\v c}ek and Zden{\v e}k Dvo{\v r}{\'a}k and Muhammad Altaf and Manzar Sohail and Isab, \{Anvarhusein A.\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2018",

month = jan,

day = "15",

doi = "10.1016/j.molstruc.2017.09.068",

language = "English",

volume = "1152",

pages = "232--236",

journal = "Journal of Molecular Structure",

issn = "0022-2860",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Synthesis, crystal structure and anticancer activity of tetrakis(N-isopropylimidazolidine-2-selenone)platinum(II) chloride

AU - Ahmad, Saeed

AU - Altoum, Ali Osman S.

AU - Vančo, Ján

AU - Křikavová, Radka

AU - Trávníček, Zdeněk

AU - Dvořák, Zdeněk

AU - Altaf, Muhammad

AU - Sohail, Manzar

AU - Isab, Anvarhusein A.

PY - 2018/1/15

Y1 - 2018/1/15

N2 - A Platinum(II) complex of N-isopropylimidazolidine-2-selenone (i-PrImSe), [Pt(i-PrImSe)4]Cl2 (1) was prepared and characterized by elemental analysis, IR and NMR (1H, 13C, 77Se & 195Pt) spectroscopy, and X-ray crystallography. The structure of 1 consists of [Pt(i-PrImSe)4]2+ complex ion and chloride counter ions. The platinum(II) atom adopts a distorted square planar geometry. The in vitro antitumor activity of 1 as well as cisplatin, was evaluated by MTT assay against human; ovarian carcinoma A2780 and its cisplatin-resistant subline A2780R, prostate cancer 22Rv1 and breast cancer MCF-7 cell lines. The title complex displayed the activity against the A2780 cells (IC50 = 30.8 μM) at the level comparable to cisplatin (IC50 = 26.8 μM). The interaction studies with sulfur-containing biomolecules revealed its ability to form a variety of intermediates and oxidized species with L-cysteine and reduced glutathione.

AB - A Platinum(II) complex of N-isopropylimidazolidine-2-selenone (i-PrImSe), [Pt(i-PrImSe)4]Cl2 (1) was prepared and characterized by elemental analysis, IR and NMR (1H, 13C, 77Se & 195Pt) spectroscopy, and X-ray crystallography. The structure of 1 consists of [Pt(i-PrImSe)4]2+ complex ion and chloride counter ions. The platinum(II) atom adopts a distorted square planar geometry. The in vitro antitumor activity of 1 as well as cisplatin, was evaluated by MTT assay against human; ovarian carcinoma A2780 and its cisplatin-resistant subline A2780R, prostate cancer 22Rv1 and breast cancer MCF-7 cell lines. The title complex displayed the activity against the A2780 cells (IC50 = 30.8 μM) at the level comparable to cisplatin (IC50 = 26.8 μM). The interaction studies with sulfur-containing biomolecules revealed its ability to form a variety of intermediates and oxidized species with L-cysteine and reduced glutathione.

KW - Anticancer activity

KW - Cisplatin

KW - N-Isopropylimidazolidine-2-selenone

KW - Platinum(II) complex

KW - X-ray structure

UR - https://www.scopus.com/pages/publications/85030166546

U2 - 10.1016/j.molstruc.2017.09.068

DO - 10.1016/j.molstruc.2017.09.068

M3 - Article

AN - SCOPUS:85030166546

SN - 0022-2860

VL - 1152

SP - 232

EP - 236

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

ER -

Synthesis, crystal structure and anticancer activity of tetrakis(N-isopropylimidazolidine-2-selenone)platinum(II) chloride

Abstract

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Keywords

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