Synthesis, characterization and anticancer evaluation of transplatin derivatives with heterocyclic thiones

Mohammed Y. Jomaa; Muhammad Altaf; Saeed Ahmad; Ali Alhoshani; Nadeem Baig; Abdel Nasser Kawde; Gaurav Bhatia; Jatinder Singh; Anvarhusein A. Isab

doi:10.1016/j.poly.2017.12.016

Synthesis, characterization and anticancer evaluation of transplatin derivatives with heterocyclic thiones

Mohammed Y. Jomaa
, Muhammad Altaf
, Saeed Ahmad
, Ali Alhoshani
, Nadeem Baig
, Abdel Nasser Kawde
, Gaurav Bhatia
, Jatinder Singh
, Anvarhusein A. Isab

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Platinum(II) complexes of heterocyclic thiones (L) based on transplatin having the general formula, trans-[Pt(NH₃)₂(Thione)₂](NO₃)₂ have been synthesized and characterized using elemental analysis, IR, and NMR (¹H & ¹³C) spectroscopy. The crystal structures of two of them, trans-[Pt(NH₃)₂(Imt)₂](NO₃)₂ (1) and trans-[Pt(NH₃)₂(Me₂Imt)₂](NO₃)₂ (3) were determined by X-ray crystallography. The structures of 1 and 3 consist of trans-[Pt(NH₃)₂L₂]²⁺ complex ions and nitrate counter ions. The platinum atom in both the complex ions adopts a distorted square planar geometry. The spectroscopic data indicated the coordination of thione ligands to platinum(II). The in vitro cytotoxicity of these compounds as well as of cisplatin and carboplatin was investigated using MTT assay against three human cancer cell lines, which are; A549 (lung carcinoma), MCF-7 (breast carcinoma) and HTC15 (colon cancer). The in vitro cytotoxicity in several cases is comparable or even higher, than carboplatin and in two cases than cisplatin.

Original language	English
Pages (from-to)	360-368
Number of pages	9
Journal	Polyhedron
Volume	141
DOIs	https://doi.org/10.1016/j.poly.2017.12.016
State	Published - 15 Feb 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer evaluation
Cytotoxicity
Heterocyclic thiones
Transplatin
X-ray structure

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10.1016/j.poly.2017.12.016

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@article{3cef6fb4e8084178998aece4b4583e71,

title = "Synthesis, characterization and anticancer evaluation of transplatin derivatives with heterocyclic thiones",

abstract = "Platinum(II) complexes of heterocyclic thiones (L) based on transplatin having the general formula, trans-[Pt(NH3)2(Thione)2](NO3)2 have been synthesized and characterized using elemental analysis, IR, and NMR (1H \& 13C) spectroscopy. The crystal structures of two of them, trans-[Pt(NH3)2(Imt)2](NO3)2 (1) and trans-[Pt(NH3)2(Me2Imt)2](NO3)2 (3) were determined by X-ray crystallography. The structures of 1 and 3 consist of trans-[Pt(NH3)2L2]2+ complex ions and nitrate counter ions. The platinum atom in both the complex ions adopts a distorted square planar geometry. The spectroscopic data indicated the coordination of thione ligands to platinum(II). The in vitro cytotoxicity of these compounds as well as of cisplatin and carboplatin was investigated using MTT assay against three human cancer cell lines, which are; A549 (lung carcinoma), MCF-7 (breast carcinoma) and HTC15 (colon cancer). The in vitro cytotoxicity in several cases is comparable or even higher, than carboplatin and in two cases than cisplatin.",

keywords = "Anticancer evaluation, Cytotoxicity, Heterocyclic thiones, Transplatin, X-ray structure",

author = "Jomaa, \{Mohammed Y.\} and Muhammad Altaf and Saeed Ahmad and Ali Alhoshani and Nadeem Baig and Kawde, \{Abdel Nasser\} and Gaurav Bhatia and Jatinder Singh and Isab, \{Anvarhusein A.\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2018",

month = feb,

day = "15",

doi = "10.1016/j.poly.2017.12.016",

language = "English",

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TY - JOUR

T1 - Synthesis, characterization and anticancer evaluation of transplatin derivatives with heterocyclic thiones

AU - Jomaa, Mohammed Y.

AU - Altaf, Muhammad

AU - Ahmad, Saeed

AU - Alhoshani, Ali

AU - Baig, Nadeem

AU - Kawde, Abdel Nasser

AU - Bhatia, Gaurav

AU - Singh, Jatinder

AU - Isab, Anvarhusein A.

PY - 2018/2/15

Y1 - 2018/2/15

N2 - Platinum(II) complexes of heterocyclic thiones (L) based on transplatin having the general formula, trans-[Pt(NH3)2(Thione)2](NO3)2 have been synthesized and characterized using elemental analysis, IR, and NMR (1H & 13C) spectroscopy. The crystal structures of two of them, trans-[Pt(NH3)2(Imt)2](NO3)2 (1) and trans-[Pt(NH3)2(Me2Imt)2](NO3)2 (3) were determined by X-ray crystallography. The structures of 1 and 3 consist of trans-[Pt(NH3)2L2]2+ complex ions and nitrate counter ions. The platinum atom in both the complex ions adopts a distorted square planar geometry. The spectroscopic data indicated the coordination of thione ligands to platinum(II). The in vitro cytotoxicity of these compounds as well as of cisplatin and carboplatin was investigated using MTT assay against three human cancer cell lines, which are; A549 (lung carcinoma), MCF-7 (breast carcinoma) and HTC15 (colon cancer). The in vitro cytotoxicity in several cases is comparable or even higher, than carboplatin and in two cases than cisplatin.

AB - Platinum(II) complexes of heterocyclic thiones (L) based on transplatin having the general formula, trans-[Pt(NH3)2(Thione)2](NO3)2 have been synthesized and characterized using elemental analysis, IR, and NMR (1H & 13C) spectroscopy. The crystal structures of two of them, trans-[Pt(NH3)2(Imt)2](NO3)2 (1) and trans-[Pt(NH3)2(Me2Imt)2](NO3)2 (3) were determined by X-ray crystallography. The structures of 1 and 3 consist of trans-[Pt(NH3)2L2]2+ complex ions and nitrate counter ions. The platinum atom in both the complex ions adopts a distorted square planar geometry. The spectroscopic data indicated the coordination of thione ligands to platinum(II). The in vitro cytotoxicity of these compounds as well as of cisplatin and carboplatin was investigated using MTT assay against three human cancer cell lines, which are; A549 (lung carcinoma), MCF-7 (breast carcinoma) and HTC15 (colon cancer). The in vitro cytotoxicity in several cases is comparable or even higher, than carboplatin and in two cases than cisplatin.

KW - Anticancer evaluation

KW - Cytotoxicity

KW - Heterocyclic thiones

KW - Transplatin

KW - X-ray structure

UR - https://www.scopus.com/pages/publications/85040012333

U2 - 10.1016/j.poly.2017.12.016

DO - 10.1016/j.poly.2017.12.016

M3 - Article

AN - SCOPUS:85040012333

SN - 0277-5387

VL - 141

SP - 360

EP - 368

JO - Polyhedron

JF - Polyhedron

ER -

Synthesis, characterization and anticancer evaluation of transplatin derivatives with heterocyclic thiones

Abstract

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Keywords

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