Synthesis, antiproliferative evaluation and in silico studies of new quinazoline derivatives as VEGFR-2 inhibitors

Biochemistry, Genetics and Molecular Biology

• In Silico Study 100%
• Kinase Insert Domain Receptor 100%
• Cancer Cell 50%
• IC50 33%
• Antineoplastic Activity 33%
• Cytotoxicity 33%
• Cell-Cycle Analysis 33%
• Colon 33%
• ADMET 33%
• Anticancer 16%
• Programmed Cell Death 16%
• Binding Affinity 16%
• Docking (Molecular) 16%
• Pharmacokinetic 16%
• Lipocortin 16%
• Cell Cycle Arrest 16%
• Cell Cycle Checkpoint 16%
• G1/S Transition 16%
• GI50 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Cell-Cycle Analysis 33%