Abstract
A series of N-(2-benzoylbenzofuran-3-yl)-4-(substituted) butanamides (IVa-f) were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. All the compounds was found active in MES tests. Compounds IVb, IVc, IVd and IVf were found to be potent and had activity at lower dose of 30mg/ kg in MES-test. Compounds IVa and IVe were less toxic as compared with the standard drug phenytoin.
| Original language | English |
|---|---|
| Pages (from-to) | 17-20 |
| Number of pages | 4 |
| Journal | Indian Journal of Heterocyclic Chemistry |
| Volume | 22 |
| Issue number | 1 |
| State | Published - Jul 2012 |
| Externally published | Yes |