Synthesis, anticancer activity and apoptosis induction of gold(I) complexes containing tris(o-methoxyphenyl)phosphane

Adam A.A. Sulaiman; Ali Alhoshani; Saeed Ahmad; Abdul Malik Puthan Peedikakkal; Ahmed K. Abogosh; Meshal Alghanem; Mohamed A. Mahmoud; W. A. Alanazi; Noura Alasmael; Muhammad Monim-ul-Mehboob; Anvarhusein A. Isab

doi:10.1016/j.ica.2021.120567

Synthesis, anticancer activity and apoptosis induction of gold(I) complexes containing tris(o-methoxyphenyl)phosphane

Adam A.A. Sulaiman
, Ali Alhoshani
, Saeed Ahmad
, Abdul Malik Puthan Peedikakkal
, Ahmed K. Abogosh
, Meshal Alghanem
, Mohamed A. Mahmoud
, W. A. Alanazi
, Noura Alasmael
, Muhammad Monim-ul-Mehboob
, Anvarhusein A. Isab

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Four new phosphanegold(I) complexes; [Au{(o-MeO-Ph)₃P}Cl] (1), [Au{(o-MeO-Ph)₃P}{(Me-Et-Ph)P}]Cl (2), [Au{(o-MeO-Ph)₃P}(Ph₃P)]Cl (3) and [Au{(o-MeO-Ph)₃P}₂]Cl (4) (where o-MeO-Ph)₃P = tris(o-methoxyphenyl)phosphane and (Me-Et-Ph)P = methylethylphenylphosphane) were prepared and characterized by elemental analysis, FTIR and NMR spectroscopy. The structure of one of the complexes was determined by X-ray crystallography, which showed that the gold(I) atom is linearly coordinated to the phosphorus and Cl atoms. The in vitro cytotoxicity of the complexes was investigated against four human cancer cell lines; A549, HeLa, MDA-MB-231 and MCF7. In all cases, the tested complexes showed excellent cytotoxicity for the selected cells, with IC₅₀ values much less than cisplatin. In order to know the possible mode of cell death, complex 1 was further evaluated for induction of apoptosis towards the A549 cells. The results indicated that the apoptosis induction increases with the complex concentration.

Original language	English
Article number	120567
Journal	Inorganica Chimica Acta
Volume	527
DOIs	https://doi.org/10.1016/j.ica.2021.120567
State	Published - 1 Nov 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer activity
Gold(I)
Phosphanes
X-ray structure

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10.1016/j.ica.2021.120567

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Sulaiman, A. A. A., Alhoshani, A., Ahmad, S., Peedikakkal, A. M. P., Abogosh, A. K., Alghanem, M., Mahmoud, M. A., Alanazi, W. A., Alasmael, N., Monim-ul-Mehboob, M., & Isab, A. A. (2021). Synthesis, anticancer activity and apoptosis induction of gold(I) complexes containing tris(o-methoxyphenyl)phosphane. Inorganica Chimica Acta, 527, Article 120567. https://doi.org/10.1016/j.ica.2021.120567

@article{30903d170c544ff88b6266da511d084a,

title = "Synthesis, anticancer activity and apoptosis induction of gold(I) complexes containing tris(o-methoxyphenyl)phosphane",

abstract = "Four new phosphanegold(I) complexes; [Au\{(o-MeO-Ph)3P\}Cl] (1), [Au\{(o-MeO-Ph)3P\}\{(Me-Et-Ph)P\}]Cl (2), [Au\{(o-MeO-Ph)3P\}(Ph3P)]Cl (3) and [Au\{(o-MeO-Ph)3P\}2]Cl (4) (where o-MeO-Ph)3P = tris(o-methoxyphenyl)phosphane and (Me-Et-Ph)P = methylethylphenylphosphane) were prepared and characterized by elemental analysis, FTIR and NMR spectroscopy. The structure of one of the complexes was determined by X-ray crystallography, which showed that the gold(I) atom is linearly coordinated to the phosphorus and Cl atoms. The in vitro cytotoxicity of the complexes was investigated against four human cancer cell lines; A549, HeLa, MDA-MB-231 and MCF7. In all cases, the tested complexes showed excellent cytotoxicity for the selected cells, with IC50 values much less than cisplatin. In order to know the possible mode of cell death, complex 1 was further evaluated for induction of apoptosis towards the A549 cells. The results indicated that the apoptosis induction increases with the complex concentration.",

keywords = "Anticancer activity, Gold(I), Phosphanes, X-ray structure",

author = "Sulaiman, \{Adam A.A.\} and Ali Alhoshani and Saeed Ahmad and Peedikakkal, \{Abdul Malik Puthan\} and Abogosh, \{Ahmed K.\} and Meshal Alghanem and Mahmoud, \{Mohamed A.\} and Alanazi, \{W. A.\} and Noura Alasmael and Muhammad Monim-ul-Mehboob and Isab, \{Anvarhusein A.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = nov,

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doi = "10.1016/j.ica.2021.120567",

language = "English",

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T1 - Synthesis, anticancer activity and apoptosis induction of gold(I) complexes containing tris(o-methoxyphenyl)phosphane

AU - Sulaiman, Adam A.A.

AU - Alhoshani, Ali

AU - Ahmad, Saeed

AU - Peedikakkal, Abdul Malik Puthan

AU - Abogosh, Ahmed K.

AU - Alghanem, Meshal

AU - Mahmoud, Mohamed A.

AU - Alanazi, W. A.

AU - Alasmael, Noura

AU - Monim-ul-Mehboob, Muhammad

AU - Isab, Anvarhusein A.

PY - 2021/11/1

Y1 - 2021/11/1

N2 - Four new phosphanegold(I) complexes; [Au{(o-MeO-Ph)3P}Cl] (1), [Au{(o-MeO-Ph)3P}{(Me-Et-Ph)P}]Cl (2), [Au{(o-MeO-Ph)3P}(Ph3P)]Cl (3) and [Au{(o-MeO-Ph)3P}2]Cl (4) (where o-MeO-Ph)3P = tris(o-methoxyphenyl)phosphane and (Me-Et-Ph)P = methylethylphenylphosphane) were prepared and characterized by elemental analysis, FTIR and NMR spectroscopy. The structure of one of the complexes was determined by X-ray crystallography, which showed that the gold(I) atom is linearly coordinated to the phosphorus and Cl atoms. The in vitro cytotoxicity of the complexes was investigated against four human cancer cell lines; A549, HeLa, MDA-MB-231 and MCF7. In all cases, the tested complexes showed excellent cytotoxicity for the selected cells, with IC50 values much less than cisplatin. In order to know the possible mode of cell death, complex 1 was further evaluated for induction of apoptosis towards the A549 cells. The results indicated that the apoptosis induction increases with the complex concentration.

AB - Four new phosphanegold(I) complexes; [Au{(o-MeO-Ph)3P}Cl] (1), [Au{(o-MeO-Ph)3P}{(Me-Et-Ph)P}]Cl (2), [Au{(o-MeO-Ph)3P}(Ph3P)]Cl (3) and [Au{(o-MeO-Ph)3P}2]Cl (4) (where o-MeO-Ph)3P = tris(o-methoxyphenyl)phosphane and (Me-Et-Ph)P = methylethylphenylphosphane) were prepared and characterized by elemental analysis, FTIR and NMR spectroscopy. The structure of one of the complexes was determined by X-ray crystallography, which showed that the gold(I) atom is linearly coordinated to the phosphorus and Cl atoms. The in vitro cytotoxicity of the complexes was investigated against four human cancer cell lines; A549, HeLa, MDA-MB-231 and MCF7. In all cases, the tested complexes showed excellent cytotoxicity for the selected cells, with IC50 values much less than cisplatin. In order to know the possible mode of cell death, complex 1 was further evaluated for induction of apoptosis towards the A549 cells. The results indicated that the apoptosis induction increases with the complex concentration.

KW - Anticancer activity

KW - Gold(I)

KW - Phosphanes

KW - X-ray structure

UR - https://www.scopus.com/pages/publications/85114162284

U2 - 10.1016/j.ica.2021.120567

DO - 10.1016/j.ica.2021.120567

M3 - Article

AN - SCOPUS:85114162284

SN - 0020-1693

VL - 527

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

M1 - 120567

ER -

Synthesis, anticancer activity and apoptosis induction of gold(I) complexes containing tris(o-methoxyphenyl)phosphane

Abstract

UN SDGs

Keywords

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