Synthesis and biological evaluation of 99mTc-labetalol for β1-adrenoceptor-mediated cardiac imaging

M. E. Moustapha; M. A. Motaleb; M. H. Sanad

doi:10.1007/s10967-015-4622-3

Synthesis and biological evaluation of ^99mTc-labetalol for β₁-adrenoceptor-mediated cardiac imaging

M. E. Moustapha, M. A. Motaleb, M. H. Sanad

Chemistry

Egyptian Atomic Energy Authority

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The objective of this work was to set up a method to formulate a complex for the assessment of myocardial infarction in vivo. Labetalol was successfully labeled with ^99mTc using SnCl₂·2H₂O as reducing agent. Various reaction parameters were investigated to optimize the labeling yield. The labeled complex was stable for up to 24 h. The heart uptake was 35.5 % ID/Organ at 5 min post-injection, while the clearance pathways from the body behave via both the hepatobiliary and renal routes.

Original language	English
Pages (from-to)	511-516
Number of pages	6
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	309
Issue number	2
DOIs	https://doi.org/10.1007/s10967-015-4622-3
State	Published - 1 Aug 2016

Keywords

Tc-labetalol
Imaging
Myocardial infarction
β-adrenoceptor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10967-015-4622-3

Cite this

@article{8004761d58a04122870bef1e2a75a7c9,

title = "Synthesis and biological evaluation of 99mTc-labetalol for β1-adrenoceptor-mediated cardiac imaging",

abstract = "The objective of this work was to set up a method to formulate a complex for the assessment of myocardial infarction in vivo. Labetalol was successfully labeled with 99mTc using SnCl2·2H2O as reducing agent. Various reaction parameters were investigated to optimize the labeling yield. The labeled complex was stable for up to 24 h. The heart uptake was 35.5 \% ID/Organ at 5 min post-injection, while the clearance pathways from the body behave via both the hepatobiliary and renal routes.",

keywords = "Tc-labetalol, Imaging, Myocardial infarction, β-adrenoceptor",

author = "Moustapha, \{M. E.\} and Motaleb, \{M. A.\} and Sanad, \{M. H.\}",

note = "Publisher Copyright: {\textcopyright} 2015, Akad{\'e}miai Kiad{\'o}, Budapest, Hungary.",

year = "2016",

month = aug,

day = "1",

doi = "10.1007/s10967-015-4622-3",

language = "English",

volume = "309",

pages = "511--516",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Springer Nature",

number = "2",

}

TY - JOUR

T1 - Synthesis and biological evaluation of 99mTc-labetalol for β1-adrenoceptor-mediated cardiac imaging

AU - Moustapha, M. E.

AU - Motaleb, M. A.

AU - Sanad, M. H.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - The objective of this work was to set up a method to formulate a complex for the assessment of myocardial infarction in vivo. Labetalol was successfully labeled with 99mTc using SnCl2·2H2O as reducing agent. Various reaction parameters were investigated to optimize the labeling yield. The labeled complex was stable for up to 24 h. The heart uptake was 35.5 % ID/Organ at 5 min post-injection, while the clearance pathways from the body behave via both the hepatobiliary and renal routes.

AB - The objective of this work was to set up a method to formulate a complex for the assessment of myocardial infarction in vivo. Labetalol was successfully labeled with 99mTc using SnCl2·2H2O as reducing agent. Various reaction parameters were investigated to optimize the labeling yield. The labeled complex was stable for up to 24 h. The heart uptake was 35.5 % ID/Organ at 5 min post-injection, while the clearance pathways from the body behave via both the hepatobiliary and renal routes.

KW - Tc-labetalol

KW - Imaging

KW - Myocardial infarction

KW - β-adrenoceptor

UR - http://www.scopus.com/inward/record.url?scp=84947772625&partnerID=8YFLogxK

U2 - 10.1007/s10967-015-4622-3

DO - 10.1007/s10967-015-4622-3

M3 - Article

AN - SCOPUS:84947772625

SN - 0236-5731

VL - 309

SP - 511

EP - 516

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 2

ER -