Synthesis and Biological Activities of Pyrazoline Derivatives: A Comprehensive Review

Heterocyclic compounds represent the largest and most diverse group of organic compounds. At present, many heterocyclic compounds have been prepared in increasing numbers due to widespread synthetic research and synthetic utility. Such compounds are useful in medicinal chemistry. Pyrazoline is a heterocycle with a five-membered ring containing two nitrogen atoms, exhibiting significant biological applications. This review highlights recent advances in pyrazoline derivatives synthesis, with particular focus on their biological uses. This study finds a wide variety of pyrazoline derivatives exhibiting promising biological activities, as elaborated in numerous articles. Besides, this review examines the progress achieved in employing pyrazoline derivatives in pharmaceutical and synthetic chemistry from 2020 to 2024.