Synthesis and biodistribution of 99m Tc-PyDA as a potential marker for tumor hypoxia imaging

T. M. Sakr; B. M. Essa; F. A. El-Essawy; A. A. El-Mohty

doi:10.1134/S1066362214010159

Synthesis and biodistribution of ^99m Tc-PyDA as a potential marker for tumor hypoxia imaging

T. M. Sakr
, B. M. Essa
, F. A. El-Essawy
, A. A. El-Mohty

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The ^99m Tc-pyrimidine-4,5-diamine (^99m Tc-PyDA) complex was prepared. The yield under the optimum conditions (5 mg of PyDA, pH 8, 25 μg of SnCl₂·2H₂O) was 96 ± 3%. The complex is stable in vitro for 24 h. The complex was tested on mice as potential marker for tumor hypoxia imaging. The complex showed high tumor hypoxia uptake with the target/nontarget (T/NT) ratio as high as ∼3.

Original language	English
Pages (from-to)	76-80
Number of pages	5
Journal	Radiochemistry
Volume	56
Issue number	1
DOIs	https://doi.org/10.1134/S1066362214010159
State	Published - Jan 2014
Externally published	Yes

Keywords

biodistribution
hypoxia
imaging
labeling
pyrimidine
technetium-99m
tumor

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title = "Synthesis and biodistribution of 99m Tc-PyDA as a potential marker for tumor hypoxia imaging",

abstract = "The 99m Tc-pyrimidine-4,5-diamine (99m Tc-PyDA) complex was prepared. The yield under the optimum conditions (5 mg of PyDA, pH 8, 25 μg of SnCl2·2H2O) was 96 ± 3\%. The complex is stable in vitro for 24 h. The complex was tested on mice as potential marker for tumor hypoxia imaging. The complex showed high tumor hypoxia uptake with the target/nontarget (T/NT) ratio as high as ∼3.",

keywords = "biodistribution, hypoxia, imaging, labeling, pyrimidine, technetium-99m, tumor",

author = "Sakr, \{T. M.\} and Essa, \{B. M.\} and El-Essawy, \{F. A.\} and El-Mohty, \{A. A.\}",

year = "2014",

month = jan,

doi = "10.1134/S1066362214010159",

language = "English",

volume = "56",

pages = "76--80",

journal = "Radiochemistry",

issn = "1066-3622",

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T1 - Synthesis and biodistribution of 99m Tc-PyDA as a potential marker for tumor hypoxia imaging

AU - Sakr, T. M.

AU - Essa, B. M.

AU - El-Essawy, F. A.

AU - El-Mohty, A. A.

PY - 2014/1

Y1 - 2014/1

N2 - The 99m Tc-pyrimidine-4,5-diamine (99m Tc-PyDA) complex was prepared. The yield under the optimum conditions (5 mg of PyDA, pH 8, 25 μg of SnCl2·2H2O) was 96 ± 3%. The complex is stable in vitro for 24 h. The complex was tested on mice as potential marker for tumor hypoxia imaging. The complex showed high tumor hypoxia uptake with the target/nontarget (T/NT) ratio as high as ∼3.

AB - The 99m Tc-pyrimidine-4,5-diamine (99m Tc-PyDA) complex was prepared. The yield under the optimum conditions (5 mg of PyDA, pH 8, 25 μg of SnCl2·2H2O) was 96 ± 3%. The complex is stable in vitro for 24 h. The complex was tested on mice as potential marker for tumor hypoxia imaging. The complex showed high tumor hypoxia uptake with the target/nontarget (T/NT) ratio as high as ∼3.

KW - biodistribution

KW - hypoxia

KW - imaging

KW - labeling

KW - pyrimidine

KW - technetium-99m

KW - tumor

UR - https://www.scopus.com/pages/publications/84894522690

U2 - 10.1134/S1066362214010159

DO - 10.1134/S1066362214010159

M3 - Article

AN - SCOPUS:84894522690

SN - 1066-3622

VL - 56

SP - 76

EP - 80

JO - Radiochemistry

JF - Radiochemistry

IS - 1

ER -

Synthesis and biodistribution of ^99m Tc-PyDA as a potential marker for tumor hypoxia imaging

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Keywords

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