Synthesis and antiviral activity of 3-aminoindole nucleosides of 2-Acetamido-2-deoxy-D-glucose

Adel A.H. Abdel-Rahman; Mona M. Abd El-Latif; Farag A. El-Essawy; Yousif A. Barakat

doi:10.5012/bkcs.2012.33.10.3417

Synthesis and antiviral activity of 3-aminoindole nucleosides of 2-Acetamido-2-deoxy-D-glucose

Adel A.H. Abdel-Rahman
, Mona M. Abd El-Latif
, Farag A. El-Essawy
, Yousif A. Barakat

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A new method for the construction of 3-aminoindole nucleosides of 2-acetamido-2-deoxy-D-glucose based is presented. Nitration and acetylation of the indole nucleosides by acetic anhydride-nitric acid mixture followed by reduction using silver catalyst (SNSM) impregnated on silica gel, afforded the corresponding amino indole nucleosides. The nucleosides were tested for antiviral activity against hepatitis B virus (HBV) to show different degrees of antiviral activities or inhibitory actions.

Original language	English
Pages (from-to)	3417-3422
Number of pages	6
Journal	Bulletin of the Korean Chemical Society
Volume	33
Issue number	10
DOIs	https://doi.org/10.5012/bkcs.2012.33.10.3417
State	Published - 20 Oct 2012
Externally published	Yes

Keywords

Antiviral activity
Nitroindole
Nucleosides
Silver nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5012/bkcs.2012.33.10.3417

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title = "Synthesis and antiviral activity of 3-aminoindole nucleosides of 2-Acetamido-2-deoxy-D-glucose",

abstract = "A new method for the construction of 3-aminoindole nucleosides of 2-acetamido-2-deoxy-D-glucose based is presented. Nitration and acetylation of the indole nucleosides by acetic anhydride-nitric acid mixture followed by reduction using silver catalyst (SNSM) impregnated on silica gel, afforded the corresponding amino indole nucleosides. The nucleosides were tested for antiviral activity against hepatitis B virus (HBV) to show different degrees of antiviral activities or inhibitory actions.",

keywords = "Antiviral activity, Nitroindole, Nucleosides, Silver nanoparticles",

author = "Abdel-Rahman, \{Adel A.H.\} and \{Abd El-Latif\}, \{Mona M.\} and El-Essawy, \{Farag A.\} and Barakat, \{Yousif A.\}",

year = "2012",

month = oct,

day = "20",

doi = "10.5012/bkcs.2012.33.10.3417",

language = "English",

volume = "33",

pages = "3417--3422",

journal = "Bulletin of the Korean Chemical Society",

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}

TY - JOUR

T1 - Synthesis and antiviral activity of 3-aminoindole nucleosides of 2-Acetamido-2-deoxy-D-glucose

AU - Abdel-Rahman, Adel A.H.

AU - Abd El-Latif, Mona M.

AU - El-Essawy, Farag A.

AU - Barakat, Yousif A.

PY - 2012/10/20

Y1 - 2012/10/20

N2 - A new method for the construction of 3-aminoindole nucleosides of 2-acetamido-2-deoxy-D-glucose based is presented. Nitration and acetylation of the indole nucleosides by acetic anhydride-nitric acid mixture followed by reduction using silver catalyst (SNSM) impregnated on silica gel, afforded the corresponding amino indole nucleosides. The nucleosides were tested for antiviral activity against hepatitis B virus (HBV) to show different degrees of antiviral activities or inhibitory actions.

AB - A new method for the construction of 3-aminoindole nucleosides of 2-acetamido-2-deoxy-D-glucose based is presented. Nitration and acetylation of the indole nucleosides by acetic anhydride-nitric acid mixture followed by reduction using silver catalyst (SNSM) impregnated on silica gel, afforded the corresponding amino indole nucleosides. The nucleosides were tested for antiviral activity against hepatitis B virus (HBV) to show different degrees of antiviral activities or inhibitory actions.

KW - Antiviral activity

KW - Nitroindole

KW - Nucleosides

KW - Silver nanoparticles

UR - https://www.scopus.com/pages/publications/84867867832

U2 - 10.5012/bkcs.2012.33.10.3417

DO - 10.5012/bkcs.2012.33.10.3417

M3 - Article

AN - SCOPUS:84867867832

SN - 0253-2964

VL - 33

SP - 3417

EP - 3422

JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

IS - 10

ER -

Synthesis and antiviral activity of 3-aminoindole nucleosides of 2-Acetamido-2-deoxy-D-glucose

Abstract

Keywords

UN SDGs

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