Synthesis and Antibacterial Evaluation of 5-((Methyl/ethylamino) methyl)-2-aryl-3-phenylthiazolidin-4-ones

A series of new 5-((methyl/ethylamino)methyl)-2-aryl-3-phenylthiazolidin-4-one derivatives (3a-d and 4a-d) was synthesized by treating 2-(aryl)-3-phenylthiazolidin-4-one derivatives (2a-d) with formaldehyde and dialkyl amines (dimethylamine/diethylamine) by Mannich reaction under microwave-assisted technique. Compounds (2a-d) were obtained from a series of N-(4-arylidine)aniline derivatives (1a-d) by reaction with thioglycolic acid. The structures of the synthesized compounds were confirmed on the basis of IR, 1H-NMR, 13C-NMR, and mass spectral analysis. The title compounds were screened for their antibacterial activity against Escherichia coli (Gram-negative) and Staphylococcus aureus (Grampositive).