Supramolecular structural-based fabrication of silver nanoparticles using diamide derivative of calix[4]arene: an efficient antimicrobial agent

Due to increase in infectious diseases, researchers are trying to synthesize effective, less toxic and inexpensive antimicrobial agents. For this, silver nanoparticles have been proved as potential antimicrobial agents. Therefore, in the present study, a supramolecular compound (calix[4]arene)-based silver nanoparticles (Calix–AgNPs (4)) were synthesized and applied as an efferent antimicrobial agent. The characterization of Calix–AgNPs was performed by UV–Vis, FTIR, SEM, XRD and Zetasizer techniques. Relative antimicrobial activity for synthesized calix[4]arene derivative (3) and Calix-AgNPs was explored against two types of bacteria (G + ve S. areus, and G – ve E.coli) and a fungal strain (R. stolonifer) using solution of silver nitrate salt as a reference. For antimicrobial study, five different dilutions of each compound derivative and Calix-AgNPs were prepared in acetonitrile (ACN) and deionized (DI) water, respectively. From results, it was revealed that Calix-AgNPs are efficient antimicrobial agents as compared to calix[4]arene derivative and silver salt. The minimum inhibitory value (MIC) was observed at 0.62 μg/mL against selected microorganisms for Calix-AgNPs. Graphical abstract: (Figure presented.).