TY - JOUR
T1 - Studies on β-ketoanilides
T2 - Synthesis of some new isoquinoline, pyrimido [4,5-c] isoquinoline and phenanthridine derivatives
AU - Kandeel, E. M.
AU - Hammouda, M.
AU - Sadek, E. G.
AU - Khalil, A. M.
PY - 1998/7
Y1 - 1998/7
N2 - The β-ketoanilides 1a,b or 2a,b react with the activated nitriles 3a-c to give the isoquinoline derivatives 4a-e, respectively. The pyrimido (4,5-c) isoquinoline derivatives 5a,b and 6a,b were obtained by the reaction of 4a,b with carbon disulfide and/or formamide/formic acid. The phenanthridine derivatives 10 and 11 were produced by cyclization of 1a or 2a with PPA and/or POCl3 whereas the phenanthridine derivative 13 is obtained by the action of amm. acetate on 12 which is obtained from the reaction of 1a or 2a with m-cresol in the presence of PPA. The structures of the compounds have been confirmed by their IR, 1H NMR and mass spectral data.
AB - The β-ketoanilides 1a,b or 2a,b react with the activated nitriles 3a-c to give the isoquinoline derivatives 4a-e, respectively. The pyrimido (4,5-c) isoquinoline derivatives 5a,b and 6a,b were obtained by the reaction of 4a,b with carbon disulfide and/or formamide/formic acid. The phenanthridine derivatives 10 and 11 were produced by cyclization of 1a or 2a with PPA and/or POCl3 whereas the phenanthridine derivative 13 is obtained by the action of amm. acetate on 12 which is obtained from the reaction of 1a or 2a with m-cresol in the presence of PPA. The structures of the compounds have been confirmed by their IR, 1H NMR and mass spectral data.
UR - https://www.scopus.com/pages/publications/3042901881
M3 - Article
AN - SCOPUS:3042901881
SN - 0971-1627
VL - 8
SP - 19
EP - 22
JO - Indian Journal of Heterocyclic Chemistry
JF - Indian Journal of Heterocyclic Chemistry
IS - 1
ER -