Stain-Robust Mitotic Figure Detection for the Mitosis Domain Generalization Challenge

Mostafa Jahanifar, Adam Shepard, Neda Zamanitajeddin, R. M.Saad Bashir, Mohsin Bilal, Syed Ali Khurram, Fayyaz Minhas, Nasir Rajpoot

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

14 Scopus citations

Abstract

The detection of mitotic figures from different scanners/sites remains an important topic of research, owing to its potential in assisting clinicians with tumour grading. The MItosis DOmain Generalization (MIDOG) challenge aims to test the robustness of detection models on unseen data from multiple scanners for this task. We present a short summary of the approach employed by the TIA Centre team to address this challenge. Our approach is based on a hybrid detection model, where mitotic candidates are segmented on stain normalised images, before being refined by a deep learning classifier. Cross-validation on the training images achieved the F1-score of 0.786 and 0.765 on the preliminary test set, demonstrating the generalizability of our model to unseen data from new scanners.

Original languageEnglish
Title of host publicationBiomedical Image Registration, Domain Generalisation and Out-of-Distribution Analysis - MICCAI 2021 Challenges
Subtitle of host publicationMIDOG 2021, MOOD 2021, and Learn2Reg 2021, Held in Conjunction with MICCAI 2021, Proceedings
EditorsMarc Aubreville, David Zimmerer, Mattias Heinrich
PublisherSpringer Science and Business Media Deutschland GmbH
Pages48-52
Number of pages5
ISBN (Print)9783030972806
DOIs
StatePublished - 2022
Externally publishedYes
Event24th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2021 - Strasbourg, France
Duration: 27 Sep 20211 Oct 2021

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume13166 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference24th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2021
Country/TerritoryFrance
CityStrasbourg
Period27/09/211/10/21

Keywords

  • Deep learning
  • Domain generalization
  • MIDOG
  • Mitosis detection

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