TY - JOUR
T1 - Spectroscopic and Electrochemical Studies of the Interaction of Some Gold(III) Complexes with Biologically Relevant Thiones
AU - Adam, Adam A.
AU - Omer, Khalid H.
AU - Kawde, Abdel Nasser
AU - M. Wazeer, M. I.
AU - Altaf, Muhammad
AU - Musa, Musa M.
AU - Ahmad, Saeed
AU - Isab, Anvarhusein A.
N1 - Publisher Copyright:
© 2018 Wiley Periodicals, Inc.
PY - 2018/3
Y1 - 2018/3
N2 - The interaction of gold(III) complexes, [Au(cis-DACH)Cl2]Cl and [Au(cis-DACH)2]Cl3 complexes (DACH = cis-1,2-diaminocyclohexane), with 13C, 15N-enriched thiourea (Tu) and 1,3-diazinane-2-thione ligands was investigated. The progress of these reactions was monitored by NMR (1H, 13C, and 15N) and UV–vis spectroscopy as well as square wave stripping voltammetry. The kinetic studies of the substitution reactions between the above-mentioned complexes with thiones in aqueous solutions containing 30 mM KCl, which is used to suppress the hydrolysis of the chloride complexes, were conducted. These reactions were followed under pseudo–first-order conditions as functions of ligand concentration, pH, and temperature. The activation parameters (ΔH#, ΔS#) were calculated from Eyring plots, and the negative values of ΔS≠ lend support for an associative mechanism. The kinetic data also indicated a relatively higher reactivity of [Au(cis-DACH)Cl2]Cl than that of [Au(cis-DACH)2]Cl3 toward the thiones.
AB - The interaction of gold(III) complexes, [Au(cis-DACH)Cl2]Cl and [Au(cis-DACH)2]Cl3 complexes (DACH = cis-1,2-diaminocyclohexane), with 13C, 15N-enriched thiourea (Tu) and 1,3-diazinane-2-thione ligands was investigated. The progress of these reactions was monitored by NMR (1H, 13C, and 15N) and UV–vis spectroscopy as well as square wave stripping voltammetry. The kinetic studies of the substitution reactions between the above-mentioned complexes with thiones in aqueous solutions containing 30 mM KCl, which is used to suppress the hydrolysis of the chloride complexes, were conducted. These reactions were followed under pseudo–first-order conditions as functions of ligand concentration, pH, and temperature. The activation parameters (ΔH#, ΔS#) were calculated from Eyring plots, and the negative values of ΔS≠ lend support for an associative mechanism. The kinetic data also indicated a relatively higher reactivity of [Au(cis-DACH)Cl2]Cl than that of [Au(cis-DACH)2]Cl3 toward the thiones.
UR - https://www.scopus.com/pages/publications/85041041449
U2 - 10.1002/kin.21149
DO - 10.1002/kin.21149
M3 - Article
AN - SCOPUS:85041041449
SN - 0538-8066
VL - 50
SP - 178
EP - 187
JO - International Journal of Chemical Kinetics
JF - International Journal of Chemical Kinetics
IS - 3
ER -