TY - JOUR
T1 - Sonographic vagus nerve atrophy in Parkinson's disease
T2 - Myth or fact? A systematic review and meta-analysis of recent evidence answers
AU - Abdelnaby, Ramy
AU - Moawad, Mostafa Hossam El Din
AU - Shabib, Ahmed Samy
AU - Mohamed, Khaled Ashraf
AU - Ebrahim, Mohamed Ayman
AU - Aboutaleb, Aya Moustafa
AU - Gaber, Dina Elsayed
AU - serour, Aya sayed
AU - Shamim, Muhammad A.
AU - Elberry, Mostafa H.
AU - Bedewi, Mohamed Abdelmohsen
AU - Elsayed, Mohamed
AU - Walter, Uwe
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/7
Y1 - 2023/7
N2 - Background: Parkinson's disease (PD) is a major cause of disability. We aimed to assess the benefit of ultrasonography of the vagus nerve (VN) to compare between PD and healthy controls as well as to deliver reference values of nerve cross sectional area (CSA). Materials and methods: We performed a systematic search on Medline (PubMed), Scopus, Embase, and Web of Science, up till July 25, 2022. After article selection and screening, we performed a quality assessment using the Newcastle–Ottawa Scale. Furthermore, a statistical analysis and subgroup analysis was performed. Results: Eleven studies were included with a total of 809 participants (409 PD patients and 400 controls). A statistically significant difference in the CSA of the right and left VN between PD patients and healthy controls was observed, indicating the atrophy of VN in PD patients (p < 0.00001). The subgroup meta-analysis for average measurements of VN CSA showed insignificant heterogeneity for age (I2 = 48.67%, p = 0.058), level of measurements (I2 = 57.91%, p = 0.05), and disease duration (I2 = 27.1%, p = 0.241). Conclusion: Our meta-analysis showed a sonographically detectable degree of neuronal damage in PD, which correlates with VN atrophy with high confidence. Therefore, we believe this is a potential marker for vagus neuronal lesions. Future studies are required to assess the potential clinical correlation.
AB - Background: Parkinson's disease (PD) is a major cause of disability. We aimed to assess the benefit of ultrasonography of the vagus nerve (VN) to compare between PD and healthy controls as well as to deliver reference values of nerve cross sectional area (CSA). Materials and methods: We performed a systematic search on Medline (PubMed), Scopus, Embase, and Web of Science, up till July 25, 2022. After article selection and screening, we performed a quality assessment using the Newcastle–Ottawa Scale. Furthermore, a statistical analysis and subgroup analysis was performed. Results: Eleven studies were included with a total of 809 participants (409 PD patients and 400 controls). A statistically significant difference in the CSA of the right and left VN between PD patients and healthy controls was observed, indicating the atrophy of VN in PD patients (p < 0.00001). The subgroup meta-analysis for average measurements of VN CSA showed insignificant heterogeneity for age (I2 = 48.67%, p = 0.058), level of measurements (I2 = 57.91%, p = 0.05), and disease duration (I2 = 27.1%, p = 0.241). Conclusion: Our meta-analysis showed a sonographically detectable degree of neuronal damage in PD, which correlates with VN atrophy with high confidence. Therefore, we believe this is a potential marker for vagus neuronal lesions. Future studies are required to assess the potential clinical correlation.
KW - Metaanalysis
KW - Nerve cross-sectional area
KW - Parkinson's disease
KW - Ultrasound
KW - Vagus nerve
UR - https://www.scopus.com/pages/publications/85159650744
U2 - 10.1016/j.parkreldis.2023.105451
DO - 10.1016/j.parkreldis.2023.105451
M3 - Article
C2 - 37236044
AN - SCOPUS:85159650744
SN - 1353-8020
VL - 112
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
M1 - 105451
ER -