Some new quinazolin-4(3H)-one derivatives, synthesis and antitumor activity

Ahmed Mahmoud Alafeefy

doi:10.1016/j.jscs.2011.06.019

Some new quinazolin-4(3H)-one derivatives, synthesis and antitumor activity

Ahmed Mahmoud Alafeefy

Prince Sattam Bin Abdulaziz University

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A series of some new 2,3-disubstituted-6-iodo-3H-quinazolin-4-one derivatives was prepared and screened for their in vitro antitumor activity against the human breast cancer cell line (MCF-7), human cervix carcinoma cell line (HeLa), human liver cancer cell line (HepG2) and human colon cancer cell line HCT-8. Five compounds exhibited broad spectrum antitumor activity, better than the standard drug Doxorubicin (CAS-23214-92-8) against the four tested cell lines. In the present study, MCF-7 cell line was the most sensitive one, 12 compounds were good cytotoxic towards it. The best cytotoxic results were obtained with compounds bearing allyl and/or benzyl moiety at positions 2 and/or 3 of the quinazoline nucleus.

Original language	English
Pages (from-to)	337-343
Number of pages	7
Journal	Journal of Saudi Chemical Society
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.jscs.2011.06.019
State	Published - Oct 2011
Externally published	Yes

Keywords

Anticancer
Cytotoxicity
Quinazoline
Synthesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jscs.2011.06.019

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abstract = "A series of some new 2,3-disubstituted-6-iodo-3H-quinazolin-4-one derivatives was prepared and screened for their in vitro antitumor activity against the human breast cancer cell line (MCF-7), human cervix carcinoma cell line (HeLa), human liver cancer cell line (HepG2) and human colon cancer cell line HCT-8. Five compounds exhibited broad spectrum antitumor activity, better than the standard drug Doxorubicin (CAS-23214-92-8) against the four tested cell lines. In the present study, MCF-7 cell line was the most sensitive one, 12 compounds were good cytotoxic towards it. The best cytotoxic results were obtained with compounds bearing allyl and/or benzyl moiety at positions 2 and/or 3 of the quinazoline nucleus.",

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AB - A series of some new 2,3-disubstituted-6-iodo-3H-quinazolin-4-one derivatives was prepared and screened for their in vitro antitumor activity against the human breast cancer cell line (MCF-7), human cervix carcinoma cell line (HeLa), human liver cancer cell line (HepG2) and human colon cancer cell line HCT-8. Five compounds exhibited broad spectrum antitumor activity, better than the standard drug Doxorubicin (CAS-23214-92-8) against the four tested cell lines. In the present study, MCF-7 cell line was the most sensitive one, 12 compounds were good cytotoxic towards it. The best cytotoxic results were obtained with compounds bearing allyl and/or benzyl moiety at positions 2 and/or 3 of the quinazoline nucleus.

KW - Anticancer

KW - Cytotoxicity

KW - Quinazoline

KW - Synthesis

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DO - 10.1016/j.jscs.2011.06.019

M3 - Article

AN - SCOPUS:80955142698

SN - 1319-6103

VL - 15

SP - 337

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JO - Journal of Saudi Chemical Society

JF - Journal of Saudi Chemical Society

IS - 4

ER -

Some new quinazolin-4(3H)-one derivatives, synthesis and antitumor activity

Abstract

Keywords

UN SDGs

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