Solubility of a poorly soluble immunosuppressant in different pure solvents: Measurement, correlation, thermodynamics and molecular interactions

Mohd Abul Kalam; Abdul Arif Khan; Aws Alshamsan; Anzarul Haque; Faiyaz Shakeel

doi:10.1016/j.molliq.2017.11.028

Solubility of a poorly soluble immunosuppressant in different pure solvents: Measurement, correlation, thermodynamics and molecular interactions

Mohd Abul Kalam
, Abdul Arif Khan
, Aws Alshamsan
, Anzarul Haque
, Faiyaz Shakeel

Pharmaceutics

King Saud University

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The objective of this research work was to measure the solubility of mycophenolate mofetil (MPM) in ten different pure solvents at temperatures T = 298.2 K to 318.2 K and pressure p = 0.1 MPa. The solubilities of MPM in mole fraction were obtained maximum in ethyl acetate (9.28 × 10^{− 2}) and minimum in water (4.16 × 10^{− 6}) at “T = 318.2 K” and similar trends were also observed at each temperature investigated. Higher solute-solvents molecular interactions were observed in MPM-ethyl acetate and MPM-Transcutol. Apparent thermodynamic analysis indicated an endothermic and entropy-driven dissolution of MPM in each solvent investigated.

Original language	English
Pages (from-to)	53-60
Number of pages	8
Journal	Journal of Molecular Liquids
Volume	249
DOIs	https://doi.org/10.1016/j.molliq.2017.11.028
State	Published - Jan 2018

Keywords

Activity coefficient
Dissolution thermodynamics
Immunosuppressant
Molecular interaction
Pure solvent
Solubility

Access to Document

10.1016/j.molliq.2017.11.028

Cite this

@article{3b88d496046541c999c534785938265e,

title = "Solubility of a poorly soluble immunosuppressant in different pure solvents: Measurement, correlation, thermodynamics and molecular interactions",

abstract = "The objective of this research work was to measure the solubility of mycophenolate mofetil (MPM) in ten different pure solvents at temperatures T = 298.2 K to 318.2 K and pressure p = 0.1 MPa. The solubilities of MPM in mole fraction were obtained maximum in ethyl acetate (9.28 × 10− 2) and minimum in water (4.16 × 10− 6) at “T = 318.2 K” and similar trends were also observed at each temperature investigated. Higher solute-solvents molecular interactions were observed in MPM-ethyl acetate and MPM-Transcutol. Apparent thermodynamic analysis indicated an endothermic and entropy-driven dissolution of MPM in each solvent investigated.",

keywords = "Activity coefficient, Dissolution thermodynamics, Immunosuppressant, Molecular interaction, Pure solvent, Solubility",

author = "Kalam, \{Mohd Abul\} and Khan, \{Abdul Arif\} and Aws Alshamsan and Anzarul Haque and Faiyaz Shakeel",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2018",

month = jan,

doi = "10.1016/j.molliq.2017.11.028",

language = "English",

volume = "249",

pages = "53--60",

journal = "Journal of Molecular Liquids",

issn = "0167-7322",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Solubility of a poorly soluble immunosuppressant in different pure solvents

T2 - Measurement, correlation, thermodynamics and molecular interactions

AU - Kalam, Mohd Abul

AU - Khan, Abdul Arif

AU - Alshamsan, Aws

AU - Haque, Anzarul

AU - Shakeel, Faiyaz

PY - 2018/1

Y1 - 2018/1

N2 - The objective of this research work was to measure the solubility of mycophenolate mofetil (MPM) in ten different pure solvents at temperatures T = 298.2 K to 318.2 K and pressure p = 0.1 MPa. The solubilities of MPM in mole fraction were obtained maximum in ethyl acetate (9.28 × 10− 2) and minimum in water (4.16 × 10− 6) at “T = 318.2 K” and similar trends were also observed at each temperature investigated. Higher solute-solvents molecular interactions were observed in MPM-ethyl acetate and MPM-Transcutol. Apparent thermodynamic analysis indicated an endothermic and entropy-driven dissolution of MPM in each solvent investigated.

AB - The objective of this research work was to measure the solubility of mycophenolate mofetil (MPM) in ten different pure solvents at temperatures T = 298.2 K to 318.2 K and pressure p = 0.1 MPa. The solubilities of MPM in mole fraction were obtained maximum in ethyl acetate (9.28 × 10− 2) and minimum in water (4.16 × 10− 6) at “T = 318.2 K” and similar trends were also observed at each temperature investigated. Higher solute-solvents molecular interactions were observed in MPM-ethyl acetate and MPM-Transcutol. Apparent thermodynamic analysis indicated an endothermic and entropy-driven dissolution of MPM in each solvent investigated.

KW - Activity coefficient

KW - Dissolution thermodynamics

KW - Immunosuppressant

KW - Molecular interaction

KW - Pure solvent

KW - Solubility

UR - https://www.scopus.com/pages/publications/85033411557

U2 - 10.1016/j.molliq.2017.11.028

DO - 10.1016/j.molliq.2017.11.028

M3 - Article

AN - SCOPUS:85033411557

SN - 0167-7322

VL - 249

SP - 53

EP - 60

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

ER -

Solubility of a poorly soluble immunosuppressant in different pure solvents: Measurement, correlation, thermodynamics and molecular interactions

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this