Sodium lignosulfonate capped silver nanoparticles: Synthesis, characterization and its catalytic application in the C[sbnd]N coupling reactions and study of its anti-gastric cancer effects

In this study, a bio-inspired technique is used to synthesize and characterize an Ag NPs garlanded sodium lignosulphate (Ag NPs@NaLS) without the use of any hazardous or poisonous stabilizing or reducing chemicals. The morphological and structural characteristics were evaluated using a variety of physicochemical techniques, including elemental mapping, FT-IR, SEM, TEM, EDX, XRD, and ICP-OES. Under mild circumstances, the nanocomposite was catalytically investigated in the effective N-arylation of indole via Buchwald-Hartwig C[sbnd]N coupling with various haloarenes. A relatively short reaction time was required to get an excellent yield. With minimal loss of catalytic activity, the nanocatalyst was readily recovered by centrifugation and recycled seven times. The cytotoxicity of the Ag NPs@NaLS bionanomaterial against stomach tumors was investigated further from a biological perspective. Following the MTT approach, the experiments were conducted against the typical gastric cancer cell lines AGS, and they showed notable in vitro actions to prevent their proliferation.