Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review

Mohammed B. Alshammari; Ashraf A. Aly; Akil Ahmad; Alan B. Brown; Asmaa H. Mohamed

doi:10.1039/d3ra06054c

Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review

Mohammed B. Alshammari, Ashraf A. Aly, Akil Ahmad, Alan B. Brown, Asmaa H. Mohamed

Chemistry

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives have been found to exhibit diversified biological and pharmacological activity in addition to their therapeutic properties. In view of these facts, we decided in this review to present representative synthetic approaches of the aforementioned spiro heterocycles, especially in the past 20 years.

Original language	English
Pages (from-to)	32786-32823
Number of pages	38
Journal	RSC Advances
Volume	13
Issue number	46
DOIs	https://doi.org/10.1039/d3ra06054c
State	Published - 7 Nov 2023

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title = "Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review",

abstract = "Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives have been found to exhibit diversified biological and pharmacological activity in addition to their therapeutic properties. In view of these facts, we decided in this review to present representative synthetic approaches of the aforementioned spiro heterocycles, especially in the past 20 years.",

author = "Alshammari, \{Mohammed B.\} and Aly, \{Ashraf A.\} and Akil Ahmad and Brown, \{Alan B.\} and Mohamed, \{Asmaa H.\}",

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AU - Alshammari, Mohammed B.

AU - Aly, Ashraf A.

AU - Ahmad, Akil

AU - Brown, Alan B.

AU - Mohamed, Asmaa H.

PY - 2023/11/7

Y1 - 2023/11/7

N2 - Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives have been found to exhibit diversified biological and pharmacological activity in addition to their therapeutic properties. In view of these facts, we decided in this review to present representative synthetic approaches of the aforementioned spiro heterocycles, especially in the past 20 years.

AB - Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives have been found to exhibit diversified biological and pharmacological activity in addition to their therapeutic properties. In view of these facts, we decided in this review to present representative synthetic approaches of the aforementioned spiro heterocycles, especially in the past 20 years.

UR - http://www.scopus.com/inward/record.url?scp=85177048913&partnerID=8YFLogxK

U2 - 10.1039/d3ra06054c

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SN - 2046-2069

VL - 13

SP - 32786

EP - 32823

JO - RSC Advances

JF - RSC Advances

IS - 46

ER -

Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review

Abstract

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