Recent progress in the chemistry of bicyclic 6–6 systems: chemistry of pyrido[1,2-a]pyrimidines

Khaled M. Elattar; Ramy Rabie; Mohamed M. Hammouda

doi:10.1007/s00706-016-1852-1

Recent progress in the chemistry of bicyclic 6–6 systems: chemistry of pyrido[1,2-a]pyrimidines

Khaled M. Elattar
, Ramy Rabie
, Mohamed M. Hammouda

Mansoura University

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Abstract: The present review provides a study on the structural features, reactions, and synthetic methodologies of pyrido[1,2-a]pyrimidines. Thus, the synthetic procedures and organic reactions since 2000 are described. The aim of this review is to give an overview of the diverse methodologies that have been reported on the chemistry of pyrido[1,2-a]pyrimidines. The tautomeric forms of 2-methyl-3-chloro-9-hydroxypyrido[1,2-a]pyrimidin-4-one are discussed, as well as, the biological importance and mechanistic pathways. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	601-627
Number of pages	27
Journal	Monatshefte fur Chemie
Volume	148
Issue number	4
DOIs	https://doi.org/10.1007/s00706-016-1852-1
State	Published - 1 Apr 2017
Externally published	Yes

Keywords

Binary systems
Pyrido[1,2-a]pyrimidines
Reactions
Synthesis of cyclic systems
Tautomerism
Tetracyclic systems
Tricyclic systems

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10.1007/s00706-016-1852-1

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title = "Recent progress in the chemistry of bicyclic 6–6 systems: chemistry of pyrido[1,2-a]pyrimidines",

abstract = "Abstract: The present review provides a study on the structural features, reactions, and synthetic methodologies of pyrido[1,2-a]pyrimidines. Thus, the synthetic procedures and organic reactions since 2000 are described. The aim of this review is to give an overview of the diverse methodologies that have been reported on the chemistry of pyrido[1,2-a]pyrimidines. The tautomeric forms of 2-methyl-3-chloro-9-hydroxypyrido[1,2-a]pyrimidin-4-one are discussed, as well as, the biological importance and mechanistic pathways. Graphical abstract: [Figure not available: see fulltext.]",

keywords = "Binary systems, Pyrido[1,2-a]pyrimidines, Reactions, Synthesis of cyclic systems, Tautomerism, Tetracyclic systems, Tricyclic systems",

author = "Elattar, \{Khaled M.\} and Ramy Rabie and Hammouda, \{Mohamed M.\}",

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year = "2017",

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day = "1",

doi = "10.1007/s00706-016-1852-1",

language = "English",

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journal = "Monatshefte fur Chemie",

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T1 - Recent progress in the chemistry of bicyclic 6–6 systems

T2 - chemistry of pyrido[1,2-a]pyrimidines

AU - Elattar, Khaled M.

AU - Rabie, Ramy

AU - Hammouda, Mohamed M.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Abstract: The present review provides a study on the structural features, reactions, and synthetic methodologies of pyrido[1,2-a]pyrimidines. Thus, the synthetic procedures and organic reactions since 2000 are described. The aim of this review is to give an overview of the diverse methodologies that have been reported on the chemistry of pyrido[1,2-a]pyrimidines. The tautomeric forms of 2-methyl-3-chloro-9-hydroxypyrido[1,2-a]pyrimidin-4-one are discussed, as well as, the biological importance and mechanistic pathways. Graphical abstract: [Figure not available: see fulltext.]

AB - Abstract: The present review provides a study on the structural features, reactions, and synthetic methodologies of pyrido[1,2-a]pyrimidines. Thus, the synthetic procedures and organic reactions since 2000 are described. The aim of this review is to give an overview of the diverse methodologies that have been reported on the chemistry of pyrido[1,2-a]pyrimidines. The tautomeric forms of 2-methyl-3-chloro-9-hydroxypyrido[1,2-a]pyrimidin-4-one are discussed, as well as, the biological importance and mechanistic pathways. Graphical abstract: [Figure not available: see fulltext.]

KW - Binary systems

KW - Pyrido[1,2-a]pyrimidines

KW - Reactions

KW - Synthesis of cyclic systems

KW - Tautomerism

KW - Tetracyclic systems

KW - Tricyclic systems

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U2 - 10.1007/s00706-016-1852-1

DO - 10.1007/s00706-016-1852-1

M3 - Review article

AN - SCOPUS:84994309634

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JO - Monatshefte fur Chemie

JF - Monatshefte fur Chemie

IS - 4

ER -

Recent progress in the chemistry of bicyclic 6–6 systems: chemistry of pyrido[1,2-a]pyrimidines

Abstract

Keywords

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