Rapid and efficient synthesis of 4-substituted pyrazol-5-one under microwave irradiation in solvent-free conditions

Magdy A.H. Zahran; Farag A.A. El-Essawy; Salah M. Yassin; Tarek A.R. Salem; Nader M. Boshta

doi:10.1002/ardp.200700121

Rapid and efficient synthesis of 4-substituted pyrazol-5-one under microwave irradiation in solvent-free conditions

Magdy A.H. Zahran
, Farag A.A. El-Essawy
, Salah M. Yassin
, Tarek A.R. Salem
, Nader M. Boshta

Menoufia University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

New heterocyclic compounds containing pyrazol-5-one coupled with benzimidazole, benzothiazole, benzoxazole, quinoline, naphthyridin, and pyrazole were synthesized. Comparative investigations to synthesize these interesting classes of heterocyclic compounds through conventional heating or under microwave-irradiation conditions were presented. Synthesized compounds 1a, 2a, 4k, 3a, c, 5a, b, 6b, 7a, b, d, 8a, and 9a were evaluated for their antitumor activity. Some of these compounds exhibited promising antitumor activity.

Original language	English
Pages (from-to)	591-598
Number of pages	8
Journal	Archiv der Pharmazie
Volume	340
Issue number	11
DOIs	https://doi.org/10.1002/ardp.200700121
State	Published - Nov 2007
Externally published	Yes

Keywords

Antitumor
Benzazoles
Microwave
Pyrazolone
Quinoline

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10.1002/ardp.200700121

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title = "Rapid and efficient synthesis of 4-substituted pyrazol-5-one under microwave irradiation in solvent-free conditions",

abstract = "New heterocyclic compounds containing pyrazol-5-one coupled with benzimidazole, benzothiazole, benzoxazole, quinoline, naphthyridin, and pyrazole were synthesized. Comparative investigations to synthesize these interesting classes of heterocyclic compounds through conventional heating or under microwave-irradiation conditions were presented. Synthesized compounds 1a, 2a, 4k, 3a, c, 5a, b, 6b, 7a, b, d, 8a, and 9a were evaluated for their antitumor activity. Some of these compounds exhibited promising antitumor activity.",

keywords = "Antitumor, Benzazoles, Microwave, Pyrazolone, Quinoline",

author = "Zahran, \{Magdy A.H.\} and El-Essawy, \{Farag A.A.\} and Yassin, \{Salah M.\} and Salem, \{Tarek A.R.\} and Boshta, \{Nader M.\}",

year = "2007",

month = nov,

doi = "10.1002/ardp.200700121",

language = "English",

volume = "340",

pages = "591--598",

journal = "Archiv der Pharmazie",

issn = "0365-6233",

publisher = "Wiley-VCH Verlag",

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T1 - Rapid and efficient synthesis of 4-substituted pyrazol-5-one under microwave irradiation in solvent-free conditions

AU - Zahran, Magdy A.H.

AU - El-Essawy, Farag A.A.

AU - Yassin, Salah M.

AU - Salem, Tarek A.R.

AU - Boshta, Nader M.

PY - 2007/11

Y1 - 2007/11

N2 - New heterocyclic compounds containing pyrazol-5-one coupled with benzimidazole, benzothiazole, benzoxazole, quinoline, naphthyridin, and pyrazole were synthesized. Comparative investigations to synthesize these interesting classes of heterocyclic compounds through conventional heating or under microwave-irradiation conditions were presented. Synthesized compounds 1a, 2a, 4k, 3a, c, 5a, b, 6b, 7a, b, d, 8a, and 9a were evaluated for their antitumor activity. Some of these compounds exhibited promising antitumor activity.

AB - New heterocyclic compounds containing pyrazol-5-one coupled with benzimidazole, benzothiazole, benzoxazole, quinoline, naphthyridin, and pyrazole were synthesized. Comparative investigations to synthesize these interesting classes of heterocyclic compounds through conventional heating or under microwave-irradiation conditions were presented. Synthesized compounds 1a, 2a, 4k, 3a, c, 5a, b, 6b, 7a, b, d, 8a, and 9a were evaluated for their antitumor activity. Some of these compounds exhibited promising antitumor activity.

KW - Antitumor

KW - Benzazoles

KW - Microwave

KW - Pyrazolone

KW - Quinoline

UR - https://www.scopus.com/pages/publications/36549034451

U2 - 10.1002/ardp.200700121

DO - 10.1002/ardp.200700121

M3 - Article

C2 - 17924363

AN - SCOPUS:36549034451

SN - 0365-6233

VL - 340

SP - 591

EP - 598

JO - Archiv der Pharmazie

JF - Archiv der Pharmazie

IS - 11

ER -

Rapid and efficient synthesis of 4-substituted pyrazol-5-one under microwave irradiation in solvent-free conditions

Abstract

Keywords

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