Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering

  • Shahid Ud Din Wani
  • , Mubashir Hussain Masoodi
  • , Surya Prakash Gautam
  • , H. G. Shivakumar
  • , Sultan Alshehri
  • , Mohammed M. Ghoneim
  • , Prawez Alam
  • , Faiyaz Shakeel

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Silk is a wonderful biopolymer that has a long history of medical applications. Surgical cords and medically authorised human analogues made of silk have a long history of use in management. We describe the use of silk in the treatment of eye diseases in this review by looking at the usage of silk fibroin for eye-related drug delivery applications and medication transfer to the eyes. During this ancient art endeavour, a reduced engineering project that employed silk as a platform for medicine delivery or a cell-filled matrix helped reignite interest. With considerable attention, this study explores the present usage of silk in ocular-based drug delivery. This paper also examines emerging developments with the use of silk as a biopolymer for the treatment of eye ailments. As treatment options for glaucoma, diabetic retinopathy, retinitis pigmentosa, and other retinal diseases and degenerations are developed, the trans-scleral route of drug delivery holds great promise for the selective, sustained-release delivery of these novel therapeutic compounds. We should expect a swarm of silk-inspired materials to enter clinical testing and use on the surface as the secrets of silk are unveiled. This article finishes with a discussion on potential silk power, which adds to better ideas and enhanced ocular medicine delivery.

Original languageEnglish
Article number5475
JournalPolymers
Volume14
Issue number24
DOIs
StatePublished - Dec 2022

Keywords

  • Bombyx mori
  • macromolecules
  • ocular drug delivery
  • silk fibroin
  • tissue engineering

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