Prevalence of anti-cardiolpin and anti-β₂-glycoprotein-1 antibodies in systemic lupus erythromatous patients

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease associated with a variety of antiphosphlipids (aPL) such as anti-cardiolipdin (aCL) and anti - β₂ glycoprotein-1 (aβ₂Glyp1) antibodies. . A total of 115 patients (112 males and 3 females) were referred to Rheumatology Clinic at National Ribat University hospital, Medical Military Hospital, and Private Clinic in Khartoum state, Plasma aCL and β₂ glycoprotein I antibodies were measured using ELISA technique. The prevalence of aCL autoantibody among patients was 44 (38.2 %), higher prevalence in females 42 (95 %) in contrast to males 5 %( 2/44). Low, medium and high titer of aCL were 23 (52 %), 18(41 %), and 3(7. 0 %) respectively. The prevalence of aβ₂Glyp1 autoantibody among patients was 25(21.7 %), higher prevalence in females 24(96 %) compared to males 1(4 %). aβ₂Glyp1 low titer 4(16 %), medium titer 14(56%), and high titer 7(28 %) were determined. aCL were found more frequently 44 (38.2 %) than anti- aβ₂Glyp1antibodies25 (21.7 %), both markers are elevated in females 42 (95 %), 24(96 %) than males 5 %( 2/44), 1(4 %) respectively. aCL and aβ₂Glyp1antibodies are very helpful markers in diagnosis of SLE and useful to minimize the risk for thrombosis.