Preparation of new oxadiazole acyclic nucleoside and thioglycoside analogs containing chromene moiety with antimicrobial evaluation

Mshari A. Alotaibi; Farag A.E.L. Essawy; Nader M. Boshta

doi:10.37358/rc.17.10.5861

Preparation of new oxadiazole acyclic nucleoside and thioglycoside analogs containing chromene moiety with antimicrobial evaluation

Menoufia University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

New sugar hydrazones linked to chroman ring system and their derived oxadiazole acyclic nucleoside analogs were synthesized from the substituted ethyl ester oxime derivative. The 2-sustituted 1,3,4-oxadiazole-5-thione prepared from acid hydrazide was glycosylated to afford the corresponding thioglycosides, not the N-linked glycosides. The novel compounds were evaluated for their antimicrobial activity and showed different degrees of activities.

Original language	English
Pages (from-to)	2228-2233
Number of pages	6
Journal	Revista de Chimie
Volume	68
Issue number	10
DOIs	https://doi.org/10.37358/rc.17.10.5861
State	Published - Oct 2017

Keywords

Acyclic Nucleoside
Antimicrobial
Chromene
Oxadiazole

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title = "Preparation of new oxadiazole acyclic nucleoside and thioglycoside analogs containing chromene moiety with antimicrobial evaluation",

abstract = "New sugar hydrazones linked to chroman ring system and their derived oxadiazole acyclic nucleoside analogs were synthesized from the substituted ethyl ester oxime derivative. The 2-sustituted 1,3,4-oxadiazole-5-thione prepared from acid hydrazide was glycosylated to afford the corresponding thioglycosides, not the N-linked glycosides. The novel compounds were evaluated for their antimicrobial activity and showed different degrees of activities.",

keywords = "Acyclic Nucleoside, Antimicrobial, Chromene, Oxadiazole",

author = "Alotaibi, \{Mshari A.\} and Essawy, \{Farag A.E.L.\} and Boshta, \{Nader M.\}",

year = "2017",

month = oct,

doi = "10.37358/rc.17.10.5861",

language = "English",

volume = "68",

pages = "2228--2233",

journal = "Revista de Chimie",

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TY - JOUR

T1 - Preparation of new oxadiazole acyclic nucleoside and thioglycoside analogs containing chromene moiety with antimicrobial evaluation

AU - Alotaibi, Mshari A.

AU - Essawy, Farag A.E.L.

AU - Boshta, Nader M.

PY - 2017/10

Y1 - 2017/10

N2 - New sugar hydrazones linked to chroman ring system and their derived oxadiazole acyclic nucleoside analogs were synthesized from the substituted ethyl ester oxime derivative. The 2-sustituted 1,3,4-oxadiazole-5-thione prepared from acid hydrazide was glycosylated to afford the corresponding thioglycosides, not the N-linked glycosides. The novel compounds were evaluated for their antimicrobial activity and showed different degrees of activities.

AB - New sugar hydrazones linked to chroman ring system and their derived oxadiazole acyclic nucleoside analogs were synthesized from the substituted ethyl ester oxime derivative. The 2-sustituted 1,3,4-oxadiazole-5-thione prepared from acid hydrazide was glycosylated to afford the corresponding thioglycosides, not the N-linked glycosides. The novel compounds were evaluated for their antimicrobial activity and showed different degrees of activities.

KW - Acyclic Nucleoside

KW - Antimicrobial

KW - Chromene

KW - Oxadiazole

UR - https://www.scopus.com/pages/publications/85033234308

U2 - 10.37358/rc.17.10.5861

DO - 10.37358/rc.17.10.5861

M3 - Article

AN - SCOPUS:85033234308

SN - 0034-7752

VL - 68

SP - 2228

EP - 2233

JO - Revista de Chimie

JF - Revista de Chimie

IS - 10

ER -

Preparation of new oxadiazole acyclic nucleoside and thioglycoside analogs containing chromene moiety with antimicrobial evaluation

Abstract

Keywords

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