Platelet indices as clinical markers in sudanese patients suffering from chronic liver diseases: Critical analysis

Background and Objective: Platelets play a central role in primary hemostasis. The liver play major role in thrombopoietin hormone production thus liver disease may affect the platelet production and maturation. This study was conducted to determine the influence of chronic liver diseases on platelet parameter among chronic liver disease patients. Materials and Methods: This descriptive cross-sectional study, conducted in AL-Gadarif Hospital state during the period from February to May, 2018. A total of 80 subjects were enrolled in this study. Complete blood count (including PLTs indices) was carried out in automated hematology analyzer (Sysmex-XP 300). Results: patients of this study have significantly reduced PLTs count (p = 0.000). The PDW was significantly increased among patients of chronic liver disease (p = 0.000). Regarding indices across gender, the platelet count was significantly lower in males compared with females (p = 0.022). The study revealed a significant reduction in platelets count in the 4 types of liver diseases (p = 0.038). Conclusion: Patients with chronic liver disease exhibit significant changes in platelet indices. That is varied according to the type and time duration of liver disease.