Pharmaceutical application of ionic liquids and evaluating their toxicity and biological activity

  • Parveen Begum
  • , Diya Ghosh
  • , Akil Ahmad
  • , Y. A. Maruthi
  • , Kaizar Hossain

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Ionic liquids (ILs) were identified to have a unique role in the pharmaceutical industry. ILs are defined as substances that almost entirely contain ions with a freezing point. A handful of these substances have drawn significant attention as pure, multipurpose solvents for a wide range of purposes. Ionic liquids exhibit a wide spectrum of chemical characteristics, as well as their potential for toxicity. Understanding of the components transmitting their cytotoxicity andbiological effectsarestill noticeably lacking. The thorough biophysical investigation of membrane contacts depicts ionic liquids, showing various side chains, cationic head groups, and also demonstrates variations in their binding to bilayers and impacts on lipid accumulation. Asthe ILsunder investigation show varying levels of biological activities and cytotoxicity, we shed more light on membrane interactions in this article as a potential significant factor underlying the biological differences in between compounds and provided a detailed analysis of theinteractions of membrane withnumerous Ionic liquids demonstrating different biological and structural properties. The impacts on lipid bilayers were also discussed in this research, and it was concluded that there was a connection between both the extent of membrane permeability or disruptionand the biological roles of the ionic liquids.

Original languageEnglish
Title of host publicationIonic Liquids and their Application in Green Chemistry
PublisherElsevier
Pages113-136
Number of pages24
ISBN (Electronic)9780323959315
ISBN (Print)9780323959322
DOIs
StatePublished - 1 Jan 2023
Externally publishedYes

Keywords

  • Biological activities
  • Cytotoxicity
  • Ionic liquids
  • Pharmaceutical application

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