TY - JOUR
T1 - Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development
AU - Kannampuzha, Sandra
AU - Gopalakrishnan, Abilash Valsala
AU - Padinharayil, Hafiza
AU - Alappat, Reema Rose
AU - Anilkumar, Kavya V. V.
AU - George, Alex
AU - Dey, Abhijit
AU - Vellingiri, Balachandar
AU - Madhyastha, Harishkumar
AU - Ganesan, Raja
AU - Ramesh, Thiyagarajan
AU - Jayaraj, Rama
AU - Prabakaran, D. S.
PY - 2023/6
Y1 - 2023/6
N2 - Infection with viruses, bacteria, and parasites are thought to be the underlying cause of about 8-17% of the world's cancer burden, i.e., approximately one in every five malignancies globally is caused by an infectious pathogen. Oncogenesis is thought to be aided by eleven major pathogens. It is crucial to identify microorganisms that potentially act as human carcinogens and to understand how exposure to such pathogens occur as well as the following carcinogenic pathways they induce. Gaining knowledge in this field will give important suggestions for effective pathogen-driven cancer care, control, and, ultimately, prevention. This review will mainly focus on the major onco-pathogens and the types of cancer caused by them. It will also discuss the major pathways which, when altered, lead to the progression of these cancers.
AB - Infection with viruses, bacteria, and parasites are thought to be the underlying cause of about 8-17% of the world's cancer burden, i.e., approximately one in every five malignancies globally is caused by an infectious pathogen. Oncogenesis is thought to be aided by eleven major pathogens. It is crucial to identify microorganisms that potentially act as human carcinogens and to understand how exposure to such pathogens occur as well as the following carcinogenic pathways they induce. Gaining knowledge in this field will give important suggestions for effective pathogen-driven cancer care, control, and, ultimately, prevention. This review will mainly focus on the major onco-pathogens and the types of cancer caused by them. It will also discuss the major pathways which, when altered, lead to the progression of these cancers.
KW - Bacteria
KW - Cancer
KW - Infections
KW - Pathogens
KW - Viruses
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fahdahdrgs&SrcAuth=WosAPI&KeyUT=WOS:001014475800001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.3390/pathogens12060770
DO - 10.3390/pathogens12060770
M3 - Review article
C2 - 37375460
SN - 2076-0817
VL - 12
JO - Pathogens
JF - Pathogens
IS - 6
M1 - 770
ER -
